An observational study in Bladder Cancer and Circulating Tumor Cells, sponsored by Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari. Completed at 1 site in Italy. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-01-26.
Sponsored by Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari · Observational
Very few factors may be identified as prognostic for patients with bladder cancer undergoing radical cystectomy. Recently, detection of circulating tumor cells has shown to be very promising in anticipating both the likelyhood of distant metastases and survival in patients with breast cancer, melanoma, prostate cancer and other malignancies. In the present study we both tested the detection rate of circulating tumor cells using a PCR based methodology in the peripheral blood of patients undergoing radical cystectomy, and we further correlated our results with their clinical outcome.
1,616 studies on the registry are indexed under Urinary Bladder Neoplasms; 421 are open to participants now.
This study's enrollment of 59 is below the median of 180 across 374 observational studies indexed under Urinary Bladder Neoplasms.
Browse Urinary Bladder Neoplasms studies →Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari is the lead sponsor of 44 studies on the registry; 11 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients undergoing radical cystectomy for bladder cancer and healthy volunteers
Exclusion Criteria:
Arm of patients undergoing radical cystectomy for bladder cancer providing peripheral blood samples for detection of circulating cancer cells
Genetic: Detection of circulating tumor cells in blood samples
Arm of healthy subjects not undergoing radical cystectomy providing peripheral blood samples for detection of circulating cancer cells
Genetic: Detection of circulating tumor cells in blood samples
Ficoll based isolation of mononuclear cells from the peripheral blood of patients undergoing radical cystectomy, nucleic acids extraction and, finally, PCR based detection of sequences specific to cytokeratins.
Prevalence of circulating tumor cells
This outcome measure reflects the exact number of subjects diagnosed with circulating tumor cells within the total population of subjects included in the study
Time frame: 8 years
Overall survival
Comparison of overall survival between the population of patients found with circulating tumor cells and those found without circulating tumor cells
Time frame: 8 years
This study is completed, as verified in Jan 2015. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari