An interventional study of Infant Ventilator Circuit Dual Heated with Autofeed Chamber in Pneumonia, Ventilator-Associated, sponsored by Prince of Songkla University. Terminated at 1 site in Thailand. Open to participants aged 1 Day to 1 Year. Per ClinicalTrials.gov, last updated 2023-06-13.
Sponsored by Prince of Songkla University · Not applicable, Interventional, and Health services research
The purpose of this study is to determine incidence of ventilator-associated pneumonia compared between weekly and no routine ventilator circuit changes in neonatal intensive care unit
Parents were received informed consent. Enrolled neonates was randomly assigned to 2 groups as 7-day ventilator circuit change and no change group by computerization with allocated of concealment. The investigation team opened the next sequentially numbered study pack, which was stored in the neonatal unit. The assignment sequence was generated with balance within random block sizes of 4. Stratification according to birthweight was done before randomization to control for differences in patient populations. Patient characteristics were recorded as gestational age, sex, birthweight, underlying disease, date of intubation, date of extubation, duration of mechanical ventilator, reintubation, length of hospital stay, parenteral nutrition, medication (H2-blocker, PPI, narcotic drugs), transfusion and oral immune therapy. Laboratory data and radiographic data were recorded. Both groups received similarly care as the nurse was assigned to take care of patient in ratio 1-2 patients: 1 nurse, new disposable circuits were use in both groups and the VAP prevention protocol and the endotracheal suctioning protocol which followed by an American Academy of Respiratory Care (AARC) clinical practice guidelines were performed in both groups.
When the VAP was suspected the radiographic data were reviewed by two pediatric radiologists on the day of diagnosis, 3 days prior to the diagnosis and/or 2 and 7 days after diagnosis to confirm diagnosis of VAP if there is different in the results, the consensus must be made.
392 studies on the registry are indexed under Pneumonia, Ventilator-Associated; 81 are open to participants now.
This study's enrollment of 19 is below the median of 122 across 254 interventional studies indexed under Pneumonia, Ventilator-Associated.
Browse Pneumonia, Ventilator-Associated studies →Prince of Songkla University is the lead sponsor of 112 studies on the registry; 13 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Ventilator circuit change every 7 days until extubation
Device: Infant Ventilator Circuit Dual Heated with Autofeed Chamber
No routine ventilator circuit change until soiling or malfunction or extubation
Device: Infant Ventilator Circuit Dual Heated with Autofeed Chamber
Also known as: Evaqua2, RT265
incidence of ventilator-associated pneumonia (percentage of ventilator-associated pneumonia (events)/mechanically ventilated infant)
percentage of ventilator-associated pneumonia (events)/mechanically ventilated infant
Time frame: within the first 30 days (plus or minus 7 days) after extubation
incidence of ventilator-associated pneumonia (ventilator-associated pneumonia (events)/1,000 ventilator days)
ventilator-associated pneumonia (events)/1,000 ventilator days
Time frame: within the first 30 days (plus or minus 7 days) after extubation
Mortality rate
pneumonia-specific mortality within 7 days and at discharge
Time frame: within the first 30 days (plus or minus 7 days) after discharge
This study is terminated, as verified in Jun 2023. You cannot join it, but the record below documents what was studied.
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Pneumonia, Ventilator-Associated→
Prince of Songkla University