An interventional study of Continuous Endurance Training and Pyramid Training in Coronary Artery Disease, sponsored by Paracelsus Medical University. Completed at 1 site in Austria. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-01-29.
Sponsored by Paracelsus Medical University · Not applicable, Interventional, and Treatment
It is the aim of our study to compare the effects of 6 and/or 2 years of either HIT (carried out at correctly assessed 85-95% of maximal heart rate), pyramid, or continuous endurance training, on changes of physical exercise capacity in cardiac patients.
The three exercise arms (isocaloric) are composed as follows:
Endurance training: 31 min at 65-75% HRmax, making it a total of 25min; HIT: 4x4min intervals at 85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25 min; Pyramid: One pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block of 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min.
All protocols are initiated by 5min of warm-up and end with 5min of cool-down, both at 60-70% HRmax.
Primary Outcome: Individual maximum power output in watt (Pmax). Secondary Outcome: Change of power output in watt at lactate tresholds at 2 and 4mmol/l.
5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.
This study's enrollment of 52 is below the median of 124 across 3,436 interventional studies indexed under Coronary Artery Disease.
Browse Coronary Artery Disease studies →Paracelsus Medical University is the lead sponsor of 33 studies on the registry; 7 are open to participants now.
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Exclusion Criteria:
Endurance training with constant work load 31min at 65-75% maximal heart rate (HRmax)
Other: Pyramid Training · Other: High-intensity interval training
One pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block of 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min.
Other: Continuous Endurance Training · Other: High-intensity interval training
HIT: 4x4 min intervals at85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25min.
Other: Continuous Endurance Training · Other: Pyramid Training
Endurance training with constant work load 31min at 65-75% Hrmax
One pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block of 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min.
HIT: 4x4 min intervals at85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25min.
Physical work capacity (PWC)
PWC will be measured by graded exercise testing on cycle ergometer.
Time frame: 6 weeks or 36 weeks
Heart rate
Heart rate will be measured by graded exercise testing on cycle ergometer.
Time frame: 6 weeks or 36 weeks
Blood pressure
Blood pressure will be measured by graded exercise testing on cycle ergometer.
Time frame: 6 weeks or 36 weeks
Lactate Thresholds
Lactate thresholds will be measured by graded exercise testing on cycle ergometer.
Time frame: 6 weeks or 36 weeks
Metabolical and cellular blood parameter
Blood will be taken before and after intervention
Time frame: 6 weeks or 36 weeks
BMI
BMI will be taken before and after intervention
Time frame: 6 weeks or 36 weeks
Gene expression
Gene expression will be taken before and after intervention
Time frame: 6 weeks or 36 weeks
Quality of Life
Quality of Life will be taken before and after intervention
Time frame: 6 weeks or 36 weeks
This study is completed, as verified in Jan 2021. You cannot join it, but the record below documents what was studied.
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Paracelsus Medical University