An interventional study of Combination of caffeine and theanine and Caffeine in Healthy, sponsored by Unilever R&D. Completed at 1 site in United Kingdom. Open to participants aged 18 Years to 45 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-12-04.
Sponsored by Unilever R&D · Not applicable, Interventional, and Treatment
Assess the effects of adding theanine to a caffeinated beverage on changes in blood pressure during acute mental stress.
Caffeine and (mental) stress can increase blood pressure. In a typical everyday and/or work environment they commonly coincide. Tea has the reputation of being a relaxing drink. L-theanine is an amino acid found almost exclusively in tea. In a previous study it was shown that caffeine increased blood pressure, while theanine antagonised these effects. In the current study the effect of theanine to a placebo on blood pressure are directly compared.
783 studies on the registry are indexed under Stress, Psychological; 128 are open to participants now.
This study's enrollment of 56 is below the median of 85 across 632 interventional studies indexed under Stress, Psychological.
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Exclusion Criteria:
250 mg caffeine + 200 mg theanine
Other: Combination of caffeine and theanine
250 mg caffeine
Other: Caffeine
Beverage containing caffeine and theanine
Beverage containing caffeine
Systolic blood pressure during stress
Systolic blood pressure during acute mental stress
Time frame: Between 30-45 minutes after test product intake
Diastolic blood pressure during stress
Diastolic blood pressure during acute mental stress
Time frame: Between 30-45 minutes after test product intake
Systolic blood pressure after stress
Systolic blood pressure immediately after acute mental stress
Time frame: Between 45-60 minutes after test product intake
Diastolic blood pressure after stress
Diastolic blood pressure immediately after acute mental stress
Time frame: Between 45-60 minutes after test product intake
STAI before and immediately after stress
Self-reported mental state: State-Trait Anxiety Inventory
Time frame: -15 and 45 relative to test product intake
UWIST before and immediately after stress
Self-reported mental state: University Of Wales Institute of Science and Technology mood adjective questionnaire
Time frame: -10, 45 minutes relative to test product intake
Cortisol in saliva before and immediately after stress
Concentration of cortisol in saliva
Time frame: -5, 45 min relative to test product intake
Heart rate during stress
Heart rate during acute mental stress
Time frame: Between 30-45 minutes after test product intake
Heart rate after stress
Heart rate immediately after acute mental stress
Time frame: Between 45-60 minutes after test product intake
Heart rate variability during stress
Heart rate variability during acute mental stress
Time frame: Between 30-45 minutes after test product intake
Heart rate variability after stress
Heart rate variability immediately after acute mental stress
Time frame: Between 45-60 minutes after test product intake
Performance STROOP
Task performance on STROOP task
Time frame: Between 30-45 minutes after test product intake
Performance mirror tracing
Task performance on mirror tracing task
Time frame: Between 30-45 minutes after test product intake
Systolic blood pressure, free living phase
Ambulatory systolic blood pressure during free living phase
Time frame: Between 80-270 minutes after test product intake
Diastolic blood pressure, free living phase
Ambulatory diastolic blood pressure during free living phase
Time frame: Between 80-270 minutes after test product intake
Cortisol, free living phase
Concentration of cortisol in saliva during free living phase
Time frame: 140, 200 and 260 minutes after test product intake
STAI, free living phase
Self-reported mental state: State-Trait Anxiety Inventory during free living phase
Time frame: 140, 200 and 260 minutes after test product intake
UWIST, free living phase
Self-reported mental state: University Of Wales Institute of Science and Technology) mood adjective questionnaire during free living phase
Time frame: 140, 200 and 260 minutes after test product intake
Pulse pressure during stress
Mean pulse pressure during mental stress
Time frame: Between 30-45 minutes after test product intake
Pulse pressure after stress
Mean pulse pressure after acute mental stress
Time frame: Between 45-60 minutes after test product intake
Mental wellbeing
Mental well being as assessed by on line survey an each evening during the 7 day period the accelerometer is worn.
Time frame: 7 consecutive days prior to the lab sessions
Physical activity
Habitual patterns in physical activity as measured by accelerometer
Time frame: 7 consecutive days prior to the lab sessions
STAI screening
State-Trait Anxiety Inventory (STAI) - Trait version, covariate
Time frame: Screening
CES-D
Center for Epidemiologic Studies Depression scale, covariate
Time frame: Screening
CISS
CISS coping scale, covariate
Time frame: Screening
loneliness
UCLA loneliness scale, covariate
Time frame: Screening
Perceived stress
Perceived Stress Scale, covariate
Time frame: Screening
This study is completed, as verified in Dec 2015. You cannot join it, but the record below documents what was studied.
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Unilever R&D