An interventional study of Lower eGFR for AVF construction and Higher eGFR for AVF construction in Renal Failure, Chronic, sponsored by Shanghai Changzheng Hospital. Status unknown. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2014-10-08.
Sponsored by Shanghai Changzheng Hospital · Not applicable, Interventional, and Treatment
The timing for arteriovenous fistula (AVF) creation and its effect on target organs in patients with chronic renal failure will be investigated by multicenter prospective cohort. Lower estimated glomerular filtration rate (eGFR) patients (eGFR\<10ml/min 1.73m2 for patients without diabetic kidney disease, and eGFR\<15ml/min 1.73m2 for diabetic kidney disease) and higher eGFR patients (eGFR 10-15ml/min 1.73m2 for patients without diabetic kidney disease, and eGFR 15-20ml/min 1.73m2 for diabetic kidney disease) will be proposed to undertake AVF creation. Maturation rate and time of AVF will be followed up in 3 months; primary and secondary patency rate of AVF, AVF construction on cardiac structure, function, encephalopathy, cerebral vascular lesions and cognitive function will be followed up in the next 2 years. This multicenter will provide evidence to develop guideline of timing for AVF creation
1,995 studies on the registry are indexed under Renal Insufficiency; 173 are open to participants now.
This study's planned enrollment of 2,200 is above the median of 43 across 1,504 interventional studies indexed under Renal Insufficiency.
Browse Renal Insufficiency studies →Shanghai Changzheng Hospital is the lead sponsor of 125 studies on the registry; 60 are open to participants now.
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Exclusion Criteria:
Contraindications to AVF construction:
Procedure: Lower eGFR for AVF construction
Procedure: Higher eGFR for AVF construction
Lower eGFR patients (eGFR\<10ml/min 1.73m2 for patients without diabetic kidney disease, and eGFR\<15ml/min 1.73m2 for diabetic kidney disease) are proposed to undergo AVF construction
Also known as: late AVF construction
Higher eGFR patients (eGFR 10-15ml/min 1.73m2 for patients without diabetic kidney disease, and eGFR 15-20ml/min 1.73m2 for diabetic kidney disease) are proposed to undergo AVF construction
Also known as: early AVF construction
Maturation rate of AVF
Assessed by duplex ultrasound. A mature fistula has a flow of over 500 mL/min,is less than 0.6 cm below the surface of the skin, and has a minimal diameter of 0.6 cm
Time frame: 3 months
Primary and secondary patency rate of AVF
Assessed by duplex ultrasound
Time frame: 2 years
Maturation time of AVF
Assessed by duplex ultrasound
Time frame: 3 months
Complications of AVF
Assessed by duplex ultrasound
Time frame: 2 years
AVF creation on ventricular volumes and left ventricular remodeling
Assessed by doppler echocardiography
Time frame: 2 years
AVF creation on AVF creation on brain MRI and cognitive functions
Cognitive functions are assessed by psychic and autonomy scores
Time frame: 2 years
No study locations are listed for this record.
This study is status unknown, as verified in Oct 2014. You cannot join it, but the record below documents what was studied.
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Shanghai Changzheng Hospital