An observational study in Septic Shock, sponsored by Karl-Andre Wian. Terminated at 1 site in Norway. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-04-27.
Sponsored by Karl-Andre Wian · Observational
The purpose of this study is to reveal if higher doses of vasopressors in septic shock patients correlates with cerebral vasoconstriction and lower cerebral oximetry.
The mortality with septic shock is high. Treatment includes antibiotics, intravenous fluid and drugs for circulatory support, especially the vasopressor norepinephrine. Fluids and drugs for circulatory support are to restore adequate organ perfusion. Inadequate oxygenation of the brain can give neurologic damage. Traditionally treatment is guided by surrogate markers like arterial and central venous pressure. Cerebral oximetry is a non-invasive method which measures cerebral saturation of oxygen, SCO2, and thereby expresses regional cerebral perfusion. By registering cerebral oxymetry on patients treated with vasopressors for septic shock we want to reveal if higher doses of vasopressor correlates with cerebral vasoconstriction and lower cerebral oximetry.
890 studies on the registry are indexed under Shock, Septic; 210 are open to participants now.
This study's enrollment of 15 is below the median of 100 across 309 observational studies indexed under Shock, Septic.
Browse Shock, Septic studies →This is the only study on the registry with Karl-Andre Wian as lead sponsor.
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Patients in the intensive care unit needing vasopressor for septic shock.
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Exclusion Criteria:
Measuring cerebral oxymetry (SCO2) first 24 hours in septic shock and given vasopressors.
Number of minutes of SCO2-values lower than 50 or reduced by 20% during 24 hours
SCO2 will be measured before initiating vasopressor therapy. Thereafter SCO2 are updated every 2 seconds and is measured for 24 hours.
Time frame: 24 hours
Incidence of acute myocardial infarction
Incidence of acute myocardial infarction based on international criteria
Time frame: Hospital discharge, expected 12 days at average
Use of vasopressors/inotropes
Use of vasopressors/inotropes * norepinephrine * epinephrine * dopamine * dobutamine * vasopressin * nitroprusside * glyceryltrinitrate
Time frame: Discharge from ICU, expected 5 days at average
Fluid balance
Time frame: 24 hours
Length of stay in ICU
Time frame: Discharge from ICU, expected 5 days at average
Length of stay in hospital
Time frame: Discharge from hospital, expected 10 days at average
Incidence of organ failure
Measuring Sequential Organ Failure Assessment, SOFA, score at inclusion and once daily during ICU-stay.
Time frame: Discharge from ICU, expected 5 days at average
The record gives a start of Feb 2015, a primary completion of Jan 2017 and a completion of Jan 2017. It does not say whether these dates are actual or estimated.
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This study is terminated, as verified in Apr 2017. You cannot join it, but the record below documents what was studied.
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