A Phase 4 interventional study of dexmedetomidine and dexmedetomidine in Postoperative Cognitive Dysfunction, sponsored by First Affiliated Hospital Xi'an Jiaotong University. Status unknown. Open to participants aged 65 Years to 80 Years. Per ClinicalTrials.gov, last updated 2014-08-25.
Sponsored by First Affiliated Hospital Xi'an Jiaotong University · Phase 4, Interventional, and Treatment
The purpose of this study is to identify the effects of different doses of dexmedetomidine on postoperative cognitive dysfunction in elderly hypertensive patients
264 studies on the registry are indexed under Postoperative Cognitive Complications; 54 are open to participants now.
This study's planned enrollment of 90 is below the median of 110 across 147 interventional studies indexed under Postoperative Cognitive Complications.
Browse Postoperative Cognitive Complications studies →First Affiliated Hospital Xi'an Jiaotong University is the lead sponsor of 306 studies on the registry; 86 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Continuous pump infusion dexmedetomidine with loading dose at 0.8µg.kg-1 over 10 minutes,followed Continuous pump infusion dexmedetomidine at 0.3µg.kg-1.h-1 until 30 minutes before end of operation
Drug: dexmedetomidine · Drug: midazolam,fentanyl,etomidate,Cisatracurium besylate · Drug: cisatracurium besylate,propofol,remifentanil,sevoflurane
Continuous pump infusion dexmedetomidine with loading dose at 0.8µg.kg-1 over 10 minutes,followed continuous pump infusion dexmedetomidine at 0.5µg.kg-1.h-1 until 30 minutes before end of operation
Drug: dexmedetomidine · Drug: midazolam,fentanyl,etomidate,Cisatracurium besylate · Drug: cisatracurium besylate,propofol,remifentanil,sevoflurane
Normal saline infusion will be given with the same infusion volume as group A and B
Drug: normal saline · Drug: midazolam,fentanyl,etomidate,Cisatracurium besylate · Drug: cisatracurium besylate,propofol,remifentanil,sevoflurane
Experimental: Group A, Continuous pump infusion dexmedetomidine with loading dose at 0.8µg.kg-1 over 10 minutes,followed continuous pump infusion dexmedetomidine at 0.3µg.kg-1.h-1 until 30 minutes before end of operation
Group B, Continuous pump infusion dexmedetomidine with loading dose at 0.8µg.kg-1 over 10 minutes,followed continuous pump infusion dexmedetomidine at 0.5µg.kg-1.h-1 until 30 minutes before end of operation
Group C , Normal saline infusion will be given with the same infusion volume as group A and B
Anesthesia induction : 0.05 mg.kg-1 midazolam,4\~5μg.kg-1 fentanyl,1.0\~1.5mg.kg-1etomidate and 0.15 mg.kg-1Cisatracurium besylate
Maintenance of anesthesia :Continuous pump infusion 0.05\~0.1mg.kg-1.h-1cisatracurium besylate,4\~8mg.kg-1.h-1propofol,0.1\~0.2μg.kg-1.min-1 remifentanil and sevoflurane inhalation with 0.6%\~1.0%
Change from baseline to postoperation in cognitive function
Mini-mental State Examination
Time frame: One day before operation,third day after operation,sixth day after operaion
Change from baseline to postoperation in recent memory
Rey Auditory Verbal Learning Test
Time frame: One day before operation,third day after operation,sixth day after operation
Change from baseline to postoperation in visual space and directional force
Trail Making Test A,Trail Making Test B
Time frame: One day before operation,third day after operation,sixth day after operaion
Change from baseline to postoperation in attention
Digit Span Test
Time frame: One day before operation,third day after operation,sixth day after operaion
Change from baseline to postoperation in pain scores
Visual analog scales
Time frame: One day before operation,third day after operation,sixth day after operation
Change from baseline to postoperation in depression scale
Beck Depression Inventory
Time frame: One day before operation,third day after operation,sixth day after operation
The duration of operation
Time frame: From begining of cutting skin to the end of skin closure,an expected average of 3 hours
The blood volume during the operation
Time frame: From begining of cutting skin to the end of skin closure,an expected average of 3 hours
The urine volume during operation
Time frame: From begining of cutting skin to the end of skin closure,an expected average of 3 hours
The dose of drugs used during operation
The dose of ephedrine, urapidil, atropine used during operation
Time frame: From begining of cutting skin to the end of skin closure,an expected average of 3 hours
No study locations are listed for this record.
This study is status unknown, as verified in Aug 2014. You cannot join it, but the record below documents what was studied.
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Postoperative Cognitive Complications→
First Affiliated Hospital Xi'an Jiaotong University