An interventional study of aspirin continuation and aspirin discontinuation in Coronary Artery Disease, sponsored by Seoul National University Hospital. Completed at 1 site in Korea, Republic of. Open to participants aged 20 Years to 80 Years. Per ClinicalTrials.gov, last updated 2016-04-21.
Sponsored by Seoul National University Hospital · Not applicable and Interventional
Platelet activation after off pump coronary artery bypass (OPCAB) surgery may affect thrombus formation. The purpose of this study is to assess the effects of preoperative continuation of aspirin on platelet activation after off pump coronary artery bypass surgery.
Patients undergoing OPCAB surgery will be randomized to continue preoperative aspirin or discontinue aspirin before surgery.
Platelet activation can be evaluated by measuring platelet p-selectin using flowcytometry. In this study, we will compare platelet-activated markers and conventional coagulation tests.
5,598 studies on the registry are indexed under Coronary Artery Disease; 957 are open to participants now.
This study's enrollment of 48 is below the median of 124 across 3,436 interventional studies indexed under Coronary Artery Disease.
Browse Coronary Artery Disease studies →Seoul National University Hospital is the lead sponsor of 1,860 studies on the registry; 275 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Intervention : Low-dose aspirin (\< 100mg/day) is used before OPCAB surgery in the aspirin continuation group.
Drug: aspirin continuation
Intervention: Low-dose aspirin is stopped more than 4 days before OPCAB surgery in the aspirin discontinuation group.
Drug: aspirin discontinuation
Patients are randomized to continue aspirin before OPCAB surgery.
Also known as: Low-dose aspirin (< 100mg/day)
Patients are randomized to discontinue aspirin more than 4 days before OPCAB surgery.
change from baseline in platelet p-selectin at 48 hours after operation
Primary outcome is expression of platelet p-selectin measured by flowcytometry 48 hours after OPCAB surgery in both groups.
Time frame: after induction of anesthesia(baseline), at the time of end of operation, 24 hour after operation, 48hr after operation
change from baseline in conventional coagulation tests at the time of end of operation, 24 hour after operation, and 48hr after operation
prothrombin time (international normalized ratio), activated partial thromboplastin time, fibrinogen
Time frame: after induction of anesthesia(baseline), at the time of end of operation, 24 hour after operation, 48hr after operation
change from baseline in platelet aggregation at the time of end of operation, 24 hour after operation, and 48hr after operation
prediction for stratification of bleeding risk due to antiplatelet agent using multiplate
Time frame: after induction of anesthesia(baseline), at the time of end of operation, 24 hour after operation, 48hr after operation
This study is completed, as verified in Aug 2014. You cannot join it, but the record below documents what was studied.
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Seoul National University Hospital