An observational study in Obesity, sponsored by University of Missouri-Columbia. Completed at 1 site in United States. Open to male participants aged 21 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-11-02.
Sponsored by University of Missouri-Columbia · Observational
College drinking associated with sporting events is characterized by excess alcohol, along with food intake, over the duration of hours has the potential to cause a build up of fat in the liver. Fatty liver can increase blood glucose concentrations leading to a prediabetes like state.
The present study will determine how overweight men respond to the over-consumption of alcohol/food to identify which characteristics might protect some men from fatty liver, while others might be more susceptible to this condition.
The goal of this work is to determine the direct impact of alcohol/food intake to cause acute fatty liver through the stimulation of de novo lipogenesis in 20 overweight, healthy men. Understanding individual susceptibility to alcohol-induced fatty liver will aid in the development of strategies designed to help people mitigate these risks.
Hypothesis is that 5h excess consumption of alcohol and food will increase liver triglycerides by 4% or more, in comparison to fasting state.
Subjects will participate in a single screening visit and a 24 hours in-patient stay at the clinical research center for treatment and tests.
No drugs will be used in this study, however, amounts of alcohol will be consumed to achieve, and maintain a breath alcohol at the legal limit (0.10).
The goals are to quantitate the increase in lipogenesis due to acute alcohol/food intake and to determine the effects of acute alcohol/food intake on liver-triglycerides.
925 studies on the registry are indexed under Alcohol Drinking; 172 are open to participants now.
This study's enrollment of 25 is below the median of 227 across 90 observational studies indexed under Alcohol Drinking.
Browse Alcohol Drinking studies →University of Missouri-Columbia is the lead sponsor of 357 studies on the registry; 70 are open to participants now.
Of its 42 completed or terminated interventional studies of FDA-regulated products, 28 (67%) have results posted.
Counted across the registry records on this site, refreshed daily.
Healthy and overweight sedentary men.
Exclusion Criteria:
All subjects will be under the same protocol which is eating and drinking on one afternoon.
Liver triglycerides
Liver fat will be measured twice in each subject via magnetic resonance spectroscopy, blood will be drawn hourly and metabolites will be measured enzymatically.
Time frame: will be measured before (fasting) and after 5 hours of alcohol consumption
Plan to share: No
No publications or documents are linked to this record.
This study is completed, as verified in Oct 2020. You cannot join it, but the record below documents what was studied.
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University of Missouri-Columbia