An observational study in Spinal Cord Injury, Neurogenic Detrusor Overactivity and Neurogenic Lower Urinary Tract Dysfunction, sponsored by Swiss Paraplegic Research, Nottwil. Completed at 1 site in Switzerland. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2015-11-17.
Sponsored by Swiss Paraplegic Research, Nottwil · Observational
Spinal cord injury (SCI) almost always affects bladder function as well. As a result of this bladder dysfunction, individuals with SCI have to undergo regular invasive examination of their bladder function (urodynamic examination).
The nerve growth factor (NGF) is released from smooth muscle cells of the bladder, and there are reports, that the concentration of NGF is elevated in the urine of patients with bladder dysfunction. The NGF concentration can also be measured in the blood. The concentration of NGF in the blood and urine of SCI individuals has not yet been investigated. These concentrations may correlate with the severity of bladder dysfunction, and may thus be used to replace or at least reduce the number of the more invasive urodynamic examinations.
The hypothesis that urine and blood NGF concentrations in individuals with SCI are higher compared to individuals with healthy bladder function will be tested.
1,948 studies on the registry are indexed under Spinal Cord Injuries; 505 are open to participants now.
This study's enrollment of 47 is below the median of 60 across 323 observational studies indexed under Spinal Cord Injuries.
Browse Spinal Cord Injuries studies →Swiss Paraplegic Research, Nottwil is the lead sponsor of 69 studies on the registry; 9 are open to participants now.
Counted across the registry records on this site, refreshed daily.
individuals suffering from neurogenic lower urinary tract dysfunction, namely neurogenic detrusor overactivity
Control Group
Inclusion Criteria:
Exclusion Criteria:
Study Group
Inclusion Criteria:
Exclusion Criteria:
individuals with neurogenic lower urinary tract dysfunction
individuals with physiologic bladder function
urinary concentration of nerve growth factor
Time frame: day 0
serum concentration of nerve growth factor
Time frame: day 0
demographics
Time frame: day 0
urodynamics
only participants with spinal cord injury
Time frame: day 0
International Prostate Symptom Score (I-PSS)
Time frame: day 0
This study is completed, as verified in Nov 2015. You cannot join it, but the record below documents what was studied.
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Swiss Paraplegic Research, Nottwil