An interventional study of Aerobic running exercise in Decompression Sickness, Endothelial Dysfunction and Neutrophil Activation, sponsored by University Hospital of Split. Completed at 2 sites in 2 countries. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-04-21.
Sponsored by University Hospital of Split · Not applicable, Interventional, and Basic science
SCUBA diving frequently involves repetitive exposures over multiple days. The goal of this study was to see how exercise impacts microparticles (MPs), endothelial function, and venous gas emboli (VGE) over a series of dives.
16 divers in 2 groups each completed 6 dives. One group completed 3 control dives followed by 5 days rest then 3 dives preceded by exercise. The other group completed the opposite protocol. Flow-mediated dilation (FMD) data and blood for MP analysis was collected before and after each dive. VGE were monitored via transthoracic echocardiography 30, 60, and 90 min after surfacing. Exercise before diving consisted of 60 min running outdoors including 8x4 min intervals at 90% VO2max effort.
21 studies on the registry are indexed under Decompression Sickness; 6 are open to participants now.
Browse Decompression Sickness studies →University Hospital of Split is the lead sponsor of 31 studies on the registry; 9 are open to participants now.
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Exclusion Criteria:
Subjects in this group complete the first 3 dives as control dives and the second 3 dives preceded by aerobic exercise
Other: Aerobic running exercise
Subjects complete the first 3 dives preceded by the intervention of aerobic exercise and the second 3 with no exercise as control dives
Other: Aerobic running exercise
60 min of aerobic intervals completed prior to SCUBA diving
Change in circulating microparticle counts
Change in circulating microparticle counts measured pre and post SCUBA diving following 6 dives spaced over 12 days
Time frame: 2 weeks
This study is completed, as verified in Apr 2014. You cannot join it, but the record below documents what was studied.
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University Hospital of Split