A Phase 4 interventional study of group 1: drug: chlorine dioxide and group 2: device: small tooth brush for tongue cleaning in Halitosis, sponsored by Ei Ei Aung. Completed at 1 site in Japan. Open to male participants aged 18 Years to 30 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-04-14.
Sponsored by Ei Ei Aung · Phase 4, Interventional, and Prevention
The purpose of the study is to evaluate the effect of various oral hygiene procedures on reduction of oral malodor.
Thirty volunteers who matched with including criteria were divided randomly into two groups. Both groups were instructed to brush their teeth with a scrubbing method for the first one week. Then, each group received the different additional oral malodor reduction regimen- in addition to tooth brushing tongue cleaning in one group and chlorine dioxide (ClO2) mouthwash in another group for three consecutive weeks. After that, all the participants were instructed to practice all the three oral hygiene procedures (tooth brushing, mouth washing, tongue cleaning) the last one week. Total volatile sulfur compounds (VSCs) measured by breathtron, tongue coating, plaque score and bleeding on probing (BOP) were outcomes of this study.
88 studies on the registry are indexed under Halitosis; 18 are open to participants now.
This study's enrollment of 30 is below the median of 45 across 75 interventional studies indexed under Halitosis.
Browse Halitosis studies →This is the only study on the registry with Ei Ei Aung as lead sponsor.
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Exclusion Criteria:
Drug: group 1: drug: chlorine dioxide 12ml chlorine dioxide (ClO2) mouthwash two times per day, for three consecutive weeks
Drug: group 1: drug: chlorine dioxide
group 2: device: small tooth brush for tongue cleaning small tooth brush for tongue cleaning
Device: group 2: device: small tooth brush for tongue cleaning
First, each group practiced tooth brushing only for one week. After that each group was requested to do the following procedures. group 1 - additional use of 12ml chlorine dioxide (ClO2) mouthwash two times per day, for three consecutive weeks besides tooth brushing. At last, each group practiced all three methods of tooth brushing, tongue cleaning, mouth washing.
Also known as: ClO2Fresh®
First, each group practiced tooth brushing only for one week. After that each group was requested to do the following procedures. group 2 - additional practice of tongue cleaning by a small tooth brush two times per day, for three consecutive weeks besides tooth brushing. At last, each group practiced all three methods of tooth brushing, tongue cleaning, mouth washing.
Volatile sulfur compounds (VSCs)
Total volatile sulfur compounds was measured by Breathron®
Time frame: 5 weeks
Bleeding on probing
gingival bleeding was recorded of bleeding was detected after examination with periodontal probe.
Time frame: 5 weeks
Tongue coating
tongue coating was evaluated by Winkel tongue coating index.
Time frame: 5weeks
Debris index
debris index was evaluated by oral hygiene index.
Time frame: 5 weeks
This study is completed, as verified in Apr 2014. You cannot join it, but the record below documents what was studied.
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