ClinicalTrials.gg
Sign In
CompletedNCT02064361Updated Feb 17, 2014

High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation

An interventional study of High intensity exercise in Decompression Sickness and SCUBA Diving, sponsored by University Hospital of Split. Completed at 2 sites in 2 countries. Open to male participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-02-17.

Sponsored by University Hospital of Split · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
10
Allocation
Not applicable
Ages
18 Years to 65 Years
Sex
Male
01

Study summary

The purpose of this study is to determine the impact of high intensity,anaerobic exercise, in the form of cycling, on SCUBA diving. Outcomes are determined by the quantification and subtype of circulating microparticles, complete blood counts, and the quantification of venous gas emboli, measured via transthoracic echocardiography, in the cardiac cavities.

02

Conditions studied

  • Decompression Sickness
  • SCUBA Diving

Keywords

  • SCUBA diving
  • exercise,
  • microparticles
  • neutrophil activation,
  • high intensity exercise
03

In context

Decompression Sickness

21 studies on the registry are indexed under Decompression Sickness; 6 are open to participants now.

Browse Decompression Sickness studies →

Lead sponsor

University Hospital of Split is the lead sponsor of 31 studies on the registry; 9 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
Male
Accepts healthy volunteers
Yes

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Experienced divers (> 250 logged dives)
  • Male
  • Physician clearance to dive

Exclusion criteria

Exclusion Criteria:

  • Prior incidence of decompression sickness
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
10 participants (actual)

Study arms

  • Experimental
    High intensity exercise

    A dive to 18 meters sea water for a duration of 41 minutes preceded by high intensity cycling

    Other: High intensity exercise

Interventions

  • OtherHigh intensity exercise

    Subjects performed a repeated Wingate protocol for the exercise condition of the study. This consisted of 4, 30 s maximal efforts on a weight-braked cycle ergometer (Monark 894E, Monark Exercise AB, Sweden) with 4 min active recovery between efforts, preceded by a 5 min warm up. The resistance was set at 7.5% bodyweight for the intervals and 2% for the warm up and active recovery periods.

06

What researchers measure

Primary outcomes

  1. Change from baseline values of number of circulating microparticles per microliter of blood

    Time frame: Prior to exercise, prior to diving, 15 and 120 minutes after surfacing

07

Study locations

2 sites
  • University of Maryland
    Baltimore, Maryland 21201, United States
  • University of Split School of Medicine
    Split, Dalmatia 21000, Croatia
08

References and documents

Publications

  • Thom SR, Milovanova TN, Bogush M, Yang M, Bhopale VM, Pollock NW, Ljubkovic M, Denoble P, Madden D, Lozo M, Dujic Z. Bubbles, microparticles, and neutrophil activation: changes with exercise level and breathing gas during open-water SCUBA diving. J Appl Physiol (1985). 2013 May 15;114(10):1396-405. doi: 10.1152/japplphysiol.00106.2013. Epub 2013 Mar 14. PubMed 23493363 ↗
09

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Feb 2013, a primary completion of May 2013 and a completion of May 2013. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Feb 12, 2014
First posted
Feb 17, 2014
Start
Feb 2013
Primary completionActual
May 2013
CompletionActual
May 2013
Last update
Feb 17, 2014
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Feb 17, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02064361
Lead sponsor
University Hospital of Split
Collaborators
University of Maryland
Responsible party
Zeljko Dujic (Professor Zeljko Dujic MD, PhD, University Hospital of Split) — Principal investigator
First posted
Feb 17, 2014
Start date
Feb 2013
Primary completion
May 2013
Completion
May 2013
Last update
Feb 17, 2014

Study contacts

Zeljko Dujic, MD. PhD
principal investigator · University Hospital of Split

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2014. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Other studies in this condition

Decompression Sickness →

Other studies from this sponsor

University Hospital of Split

Start the discussion