An interventional study of BNP in Meningococcal Infections, Septic Shock and Severe Sepsis, sponsored by Assistance Publique - Hôpitaux de Paris. Completed at 1 site in France. Open to participants aged 6 Months to 18 Years. Per ClinicalTrials.gov, last updated 2023-08-28.
Sponsored by Assistance Publique - Hôpitaux de Paris · Not applicable, Interventional, and Diagnostic
Use of brain natriuretic peptide to evaluate the cardiac function in the course of meningococcal septic shock or severe sepsis.
OBJECTIVES: determining sensibility and specificity of BNP blood level to detect myocardial dysfunction in septic shock or severe sepsis due to Neisseria meningitidis in children.
METHODS: Prospective multicentric clinical trial including 7 French pediatric intensive care units. Serial cardiac ultra sounds and blood sampling will be done for patients hospitalized for purpura fulminans beginning at the time of admission in pediatric intensive care. Any child from 6 months to 18 years without preexisting cardiac disease and presenting with purpura fulminans will be enrolled after obtaining consent of both parents. From adult's studies on septic shock and BNP, a total number of 30 patients was calculated to be necessary to prove the interest of BNP in this indication.
1,899 studies on the registry are indexed under Sepsis; 462 are open to participants now.
This study's enrollment of 35 is below the median of 105 across 896 interventional studies indexed under Sepsis.
Browse Sepsis studies →Assistance Publique - Hôpitaux de Paris is the lead sponsor of 3,505 studies on the registry; 1,006 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Repeated brain natriuretic peptide dosages and cardiac echographies up to day 5
Biological: BNP
Repeated brain natriuretic peptide dosages and cardiac echographies up to day 5
Repeated brain natriuretic peptide (BNP) blood level
Time frame: Up to day 5
Repeated cardiac echography
Time frame: Up to day 5
PRISM II gravity score
Time frame: Up to day 5
Organ failure PELOD score
Time frame: Up to day 5
Troponin rate
Time frame: Up to day 5
mortality and morbidity (aftereffects)
Time frame: Day 28 and hospital discharge
This study is completed, as verified in Aug 2023. You cannot join it, but the record below documents what was studied.
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Assistance Publique - Hôpitaux de Paris