An interventional study of aerobic and resistance training and aerobic combined with balance training in Chronic Kidney Disease, sponsored by Region Skane. Status unknown at 1 site in Sweden. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2016-09-23.
Sponsored by Region Skane · Not applicable, Interventional, and Treatment
The investigators' purpose is to study which exercise training modality: aerobic physical activity in conjunction with either resistance training or balance training, is most beneficial in patients with chronic kidney disease (CKD 4-5: GFR \< 30 ml/min/1.73mUP[2]). Furthermore, our purpose is to evaluate the long-term effects of exercise training on functional status, cardiovascular morbidity, blood pressure control, heart rate variability, cardiac function, inflammation, body composition, nutritional status, progression of uraemia and health related quality of life. This interventional study is prospective, randomized and controlled comprising 150 prevalent and incident patients from our outpatient clinic. Patients are invited to participate in the study consecutively, irrespective of basic functional status. At start patients are randomised either to resistance or balance training and the programme is adapted and individualised to each patient's actual physical status and ability. The exercise prescription is to exercise for 30 minutes/day, 5 days/week, keeping the intensity constant at a level of "somewhat strenuous" to "strenuous" on the Borg scale rate of perceived exertion. The total observation period is 12 months with checks every four months. Although exercise training is a recommended therapy in CKD, there is a lack of medical and scientific evidence on optimal prescription. We hope that this study will provide evidence-based knowledge on exercise prescription and its effects on various risk factors in CKD patients. Finally, if patients achieve a higher degree of physical functional capacity they should be able to maintain an autonomous lifestyle, resulting in considerable reductions in societal costs for care and transportation.
3,224 studies on the registry are indexed under Renal Insufficiency, Chronic; 706 are open to participants now.
This study's planned enrollment of 150 is above the median of 74 across 2,229 interventional studies indexed under Renal Insufficiency, Chronic.
Browse Renal Insufficiency, Chronic studies →Region Skane is the lead sponsor of 382 studies on the registry; 118 are open to participants now.
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Exclusion Criteria:
Regular aerobic activity combined with 3 sessions/week of resistance training totalling 150 minutes per week of physical activity
Other: aerobic and resistance training
Regular aerobic activity combined with 3 sessions/week of balance training totalling 150 minutes per week of physical activity
Other: aerobic combined with balance training
Physical function
6 minutes walking test, 30 seconds sit to stand, stair climbing, handgrip strength, Isometric quadriceps strength, functional reach, standing heel rise, toes lift, picking-up test, Berg balance scale
Time frame: 4, 8 and 12 months
Cardiovascular morbidity
Time frame: after 12 months
Body composition
Time frame: after 12 months
Quality of Life
Time frame: 4,8 and 12 months
Inflammatory activity
Time frame: 4, 8 and 12 months
Bone density
Time frame: 12 months
Compliance to exercise training protocol
Time frame: 4, 8 and 12 month
This study is status unknown, as verified in Sep 2016. You cannot join it, but the record below documents what was studied.
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Renal Insufficiency, Chronic →