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Not yet recruitingNCT07888777Updated Oct 22, 2026

Manual Acupuncture for Intradialytic Nausea and Vomiting in Patients Undergoing Hemodialysis: A Randomized Controlled Trial

An interventional study of Acupuncture and sham acupuncture in Intradialytic Nausea and Vomiting, Chronic Kidney Disease and Acupuncture, sponsored by Universitas Indonesia. Not yet recruiting at 1 site in Indonesia. Open to participants aged 18 Years to 59 Years. Per ClinicalTrials.gov, last updated 2026-10-22.

Sponsored by Universitas Indonesia · Not applicable, Interventional, and Treatment

Updated Oct 22, 2026Newly registeredGo to Updates ↓
Phase
Not applicable
Study type
Interventional
Enrollment
20
Allocation
Randomized
Ages
18 Years to 59 Years
Sex
All
01

Study summary

This study aims to evaluate the immediate effects of acupuncture therapy at three specific acupuncture points (PC6, ST36, and KI3) on intradialysis nausea and vomiting in patients with chronic kidney disease undergoing regular hemodialysis. The outcome will be assessed using the Rhodes Index of Nausea, Vomiting, and Retching (RINVR) score one hour during the treatment and two hours after completion of hemodialysis.

02

Conditions studied

  • Intradialytic Nausea and Vomiting
  • Chronic Kidney Disease
  • Acupuncture
03

In context

Vomiting

1,123 studies on the registry are indexed under Vomiting; 137 are open to participants now.

This study's planned enrollment of 20 is below the median of 105 across 954 interventional studies indexed under Vomiting.

Browse Vomiting studies →

Lead sponsor

Universitas Indonesia is the lead sponsor of 27 studies on the registry; 10 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 59 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Patients with chronic kidney disease (CKD) who experience intradialytic nausea and vomiting, undergo routine hemodialysis twice weekly for at least 6 months, and are hemodynamically stable.
  • Subjects aged 18-59 years.
  • Subjects who have not received acupuncture therapy within at least one month prior to the study.
  • Subjects who are willing to participate in the study according to the scheduled protocol until completion and who have signed the informed consent form.

Exclusion criteria

Exclusion Criteria:

  • Subjects with malignancies or infected wounds at the acupuncture point sites intended for intervention.
  • Subjects with primary skin diseases, such as allergic dermatitis, irritant contact dermatitis, neurodermatitis, and psoriasis.
  • Subjects with a history of hypersensitivity reactions to previous acupuncture therapy, including stainless steel allergy, atopy, keloid formation, or other hypersensitivity reactions.
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Double (Participant, Outcomes assessor)
Enrollment
20 participants (estimated)

Study arms

  • Experimental
    Manual Acupuncture

    Manual acupuncture is performed at bilateral PC6 (Neiguan), ST36 (Zusanli), and KI3 (Taixi) using sterile Huanqiu® needles (0.25 × 25 mm) inserted 20 mm deep through a hole in a transparent waterproof Onemed® plaster, guided by a 20-mm tube. Needles are retained for 20 minutes without manipulation and then removed, twice per treatment period. Sample are blindfolded during the procedure. Device: Manual Acupuncture The manual acupuncture is using sterile Huanqiu® needles

    Device: Acupuncture

  • Sham comparator
    Sham Acupuncture

    Manual acupuncture is performed at bilateral PC6 (Neiguan), ST36 (Zusanli), and KI3 (Taixi) using with blunt-tipped needles that only press against an intact plaster without penetrating the skin above the Onemed® plaster, pressed by a 20-mm tube, controlling for pressure sensation and expectation. Sample are blindfolded during the procedure. Device: Sham Acupuncture The sham acupuncture using blunt-tipped needles

    Device: sham acupuncture

Interventions

  • DeviceAcupuncture

    The manual acupuncture is using sterile Huanqiu® needles

  • Devicesham acupuncture

    The sham acupuncture using blunt-tipped needles

06

What researchers measure

Primary outcomes

  1. Rhodes Index of Nausea, Vomiting and Retching (RINVR)

    Time frame: baseline (after dialysis is running for 1 hour), 2 hours after dialysis is finished

07

Study locations

1 site
  • Universitas Indonesia
    Jakarta Pusat, DKI Jakarta 10430, Indonesia
08

References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Timeline

1 registry update since Sep 25, 2026
ElapsedEstimatedEstimated, not yet reachedSimilar studies: half by the dot; the band is the middle halfHalf of similar studies reached it by the dot; the band is the middle half, from a quarter to three quarters

Start is estimated for Oct 2026; primary completion for Nov 2026, 1 month later.

Of 230 non-industry interventional studies with no phase under Vomiting, half reached primary completion within 12 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 26. This study's planned 1 month is below that.

Counting every sponsor, half of 234 studies reached it within 12 months; a quarter within 6 and three quarters within 27.

How these figures are worked out, and which studies are left out of them.

Registered
Oct 15, 2026
First posted
Oct 22, 2026
StartEst.
Oct 2026
Primary completionEst.
Nov 2026
CompletionEst.
Dec 2026
Last update
Oct 22, 2026
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Primary completion.
When the last participant was examined or treated to collect data for the study's main question, its primary outcome. A study that stopped early gives the date its data collection stopped.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
Registered
First appeared on the registry. No changes since
Oct 22, 2026
Show all 1 update
  1. Oct 22, 2026
    First appeared on the registry

From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗

10

Registry details

Key details

Study ID
NCT07888777
Lead sponsor
Universitas Indonesia
Responsible party
Anthonius Santoso Rulie (MD, Universitas Indonesia) — Principal investigator
First posted
Oct 22, 2026
Start date
Oct 2026 (estimated)
Primary completion
Nov 2026 (estimated)
Completion
Dec 2026 (estimated)
Last update
Oct 22, 2026

Study contacts

Anthonius S Rulie, MD
Contact
anthoniusrulie@gmail.com
+6285942085155
Medical Acupuncture Study Program FKUI
principal investigator · Medical Acupuncture Study Program Faculty of Medicine Universitas Indonesia

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Oct 2026. You cannot join it, but the record below documents what was studied.

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