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CompletedNCT02032069Updated Mar 15, 2016

Pneumoproteins Expression in the Organ Donor

An observational study in Primary Graft Dysfunction, sponsored by University Hospital of Mont-Godinne. Completed at 1 site in Belgium. Open to participants aged 5 Years to 70 Years. Per ClinicalTrials.gov, last updated 2016-03-15.

Sponsored by University Hospital of Mont-Godinne · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
20
Ages
5 Years to 70 Years
Sex
All
01

Study summary

Primary graft dysfunction, a form of reperfusion pulmonary edema that occurs early after lung transplantation, shares key clinical and pathological features with acute lung injury and its more severe form, the acute respiratory distress syndrome. However, in contrast to acute lung injury/acute respiratory distress syndrome, in which biomarkers in plasma, urine and lung edema fluid have prognostic and pathogenetic value, the role of biomarkers in primary graft dysfunction has been less thoroughly explored. We will try in this study de determine the rule of pneumoproteins in the donor organ on the pulmonary edema in the recipient.

02

Conditions studied

  • Primary Graft Dysfunction
03

Who can participate

Ages eligible
5 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Organ donors and lung recipients

Inclusion criteria

All the organ donors for lung grafts.

Exclusion criteria

Exclusion Criteria:

none

04

Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
20 participants (actual)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • NHBD

    Non Heart Beating Donors

    Other: no intervention

  • BDD

    Brain death donors

    Other: no intervention

Interventions

  • Otherno intervention
05

What researchers measure

Primary outcomes

  1. Number of Recipient with primary graft dysfunction

    Time frame: one year

06

Study locations

1 site
  • CHU Mont-Godinne
    Yvoir, Namur 5530, Belgium
07

Registry details

Key details

Study ID
NCT02032069
Lead sponsor
University Hospital of Mont-Godinne
Responsible party
Asmae Belhaj (MD, University Hospital of Mont-Godinne) — Principal investigator
First posted
Jan 9, 2014
Start date
Jan 2013
Primary completion
Jan 2016
Completion
Jan 2016
Last update
Mar 15, 2016

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Mar 2016. You cannot join it, but the record below documents what was studied.

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