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RecruitingNCT02026843Updated Mar 6, 2025

Analysis of Biomarkers From Patients With Chorioretinal Diseases

An observational study in Diabetic Retinopathy and Macular Degeneration, sponsored by Kyungpook National University Hospital. Recruiting at 1 site in Korea, Republic of. Open to participants aged 20 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-03-06.

Sponsored by Kyungpook National University Hospital · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
100
Ages
20 Years to 80 Years
Sex
All
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Study summary

This study was conducted to investigate the levels of ocular biomarkers from the patients with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration.

Read the detailed description

This prospective, case-control study included 50 patients(50eyes) with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration. and 50 patient with nondiabetic retinopathy or cataract. Ocular fluids and blood samples were taken before injection of anti-vascular endothelial growth factor agent or pars plana vitrectomy for other retinal disease. Ocular biomarkers were analyzed.

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Conditions studied

  • Diabetic Retinopathy
  • Macular Degeneration
03

In context

Diabetic Retinopathy

778 studies on the registry are indexed under Diabetic Retinopathy; 142 are open to participants now.

This study's planned enrollment of 100 is below the median of 172 across 263 observational studies indexed under Diabetic Retinopathy.

Browse Diabetic Retinopathy studies →

Lead sponsor

Kyungpook National University Hospital is the lead sponsor of 80 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
20 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

A total of 100 patients will be included. 50 patients with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration. and 50 control patients scheduled for pars plana vitrectomy for nondiabetic retinal disease or phacoemulsification.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • age over 20 years
  • patients requiring ophthalmologic treatments for different degrees of decreasing of visual acuity.
  • patients with chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration.
  • control patients asking cataract surgery or vitrectomy for posterior segment nonproliferative disorders.

Exclusion criteria

Exclusion Criteria:

  • under the age of 20 years
  • patients that received any anti-vascular endothelial growth factor agent for proliferative disease before taking sample of aqueous humor
  • patients that did not signed the of the trial
  • patients with intraocular inflammations or infections that requiring any pharmaceutical agent
  • patients with recent ocular trauma
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

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Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
100 participants (estimated)
Patient registry
No
Biospecimen retention
Samples with dna

Groups and cohorts

  • Chorioretinal diseases

    chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration.

    Drug: Chorioretinal diseases

  • Control

    control patients with surgeries include pars plana vitrectomy of macular hole, epiretinal membrane, cataract surgery.

Interventions

  • DrugChorioretinal diseases

    chorioretinal diseases including diabetic retinopathy, retinal vascular diseases, age-related macular degeneration (dry and wet), and retinal degeneration

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What researchers measure

Primary outcomes

  1. Biomarkers in ocular fluids

    To establish if certain type of chorioretinal diseases group are associated to different concentrations of gene or protein concentration.

    Time frame: one month

07

Study locations

1 of 1 sites recruiting
  • Dong Ho Park
    Daegu, Kyungsangpookdo 700-721, Korea, Republic of
    Recruiting
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References and documents

Individual participant data

Plan to share: No

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 6, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT02026843
Lead sponsor
Kyungpook National University Hospital
Responsible party
Dong Ho Park (Department of Opthalmology, School of medicine, Kyungpook National University, Kyungpook National University Hospital) — Principal investigator
First posted
Jan 3, 2014
Start date
Apr 2012
Primary completion
Feb 2028 (estimated)
Completion
Apr 2031 (estimated)
Last update
Mar 6, 2025

Study contacts

Dong Ho Park, M.D.
Contact
sarasate2222@gmail.com
82-53-420-5813
Dong Ho Park, M.D
principal investigator · Kyungpook National University Hospital

Oversight

Data monitoring committee
Yes
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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