An interventional study of Hyperbaric Oxygen and Normal ambient conditions in Pain, Inflammation and Hyperalgesia, sponsored by Per Rotbøll Nielsen. Completed at 1 site in Denmark. Open to male participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-01-01.
Sponsored by Per Rotbøll Nielsen · Not applicable, Interventional, and Basic science
The hypothesis of this investigation is to observe if HBO have an anti-inflammatory effect in humans induced by tonic heat stimulation. It has been shown in animal studies with rats that HBO could reduce the paw edema induced by carrageenan as an inflammatory agent. The authors are not aware of similar studies in human subjects investigating this effect of HBO. Aim: To investigate the anti-inflammatory effect of HBO by reducing the hyperalgesia induced by heat stimulation in healthy subjects and promote future research and understanding of the anti-inflammatory processes in humans. The primary endpoint is a reduced area of secondary hyperalgesia after HBO.
152 studies on the registry are indexed under Hyperalgesia; 13 are open to participants now.
This study's enrollment of 16 is below the median of 42 across 127 interventional studies indexed under Hyperalgesia.
Browse Hyperalgesia studies →This is the only study on the registry with Per Rotbøll Nielsen as lead sponsor.
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Subjects will breathe oxygen (FIO2 = 1.0) at 2.4 ATA in a hyperbaric chamber after the tonic heat stimulations. The duration of oxygen exposure is 90 min
Drug: Hyperbaric Oxygen · Other: Normal ambient conditions
Subjects will breathe oxygen (FIO2 = 1.0) at 2.4 ATA in a hyperbaric chamber after the tonic heat stimulations. The duration of oxygen exposure is 90 min.
Normal ambient conditions (1 ATA, FIO2 = 0.21)
The effect of Hyperbaric Oxygen Therapy on Pain and Inflammation induced by Tonic Heat Stimulation in Human Volunteers
Inflammation
Time frame: 8 weeks
Pain on Pain Scores on the Visual Analog Scale
Time frame: 8 weeks
This study is completed, as verified in Dec 2013. You cannot join it, but the record below documents what was studied.
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