An interventional study of application of the mini-mental state test in Prelingual Deafness and Retention Disorders, Cognitive, sponsored by Lille Catholic University. Completed at 4 sites in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2019-02-15.
Sponsored by Lille Catholic University · Not applicable, Interventional, and Diagnostic
In France the prevalence of pre-lingual deafness is between 1 and 1.4 per 1000 habitants, and according to very conservative estimates, about 44 000 deaf persons use the sign language. Additionally, the prevalence of dementia in France is close to 1% (850 000 dements for a total population of 65 millions). The prevalence of dementia in pre-lingual deaf adults has also been described and is between 1 and 1.4 /100 000 habitants.
The Mini Mental State Examination (MMSE) of Folstein is a test recommended to perform the cognitive evaluation for the detection of mental disorders including dementia, and a consensual French version exists prepared by GRECO (Group of Research and Cognitive Assessments). However, to date, there are no simple, rapid and validated screening tests to study cognitive disorders in deaf persons who use the sign language. The only tests available allow a late diagnosis avoiding an optimal treatment of the patients.
The objective of this study is to assess the intrinsic quality of the tool MMS-LS, a mini-mental state examination that has been adapted to the sign language in order to monitor cognitive disorders in deaf people who speak sign language.
609 studies on the registry are indexed under Deafness; 111 are open to participants now.
This study's enrollment of 195 is above the median of 40 across 411 interventional studies indexed under Deafness.
Browse Deafness studies →Lille Catholic University is the lead sponsor of 111 studies on the registry; 26 are open to participants now.
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Exclusion Criteria:
Behavioral: application of the mini-mental state test
Assessment of internal consistency of MMS-LS test for the diagnosis of cognitive impairment among deaf patients by a correlation analysis followed by Cronbach's alpha test
Time frame: At baseline, 1 year and 2 years follow-up visits
Description of MMS-LS test results
Explanatory Factors are: age, education level, characteristics of the sign language(fluency level, learning age, usage frequency, usage by other family members)
Time frame: Baseline
Diagnostic performance and predictive values of MMS-LS test for acquired dementia.
Sensitivity, specificity, positive and negative predictive values.
Time frame: Baseline, 1 year and 2 years follow-up visits
Correlation between MMS-LS score and CDR level
We also check that patients having a suspicious CDR (0.5) have a superior MMS-LS score compared to patients having a CDR ≥ 1.
Time frame: Baseline, 1 year and 2 years follow-up visits
Diagnostic performance and predictive values of MMS-LS test for suspected dementia.
Sensitivity, specificity, positive and negative predictive values
Time frame: Baseline, 1 year and 2 years follow-up visits
This study is completed, as verified in Feb 2019. You cannot join it, but the record below documents what was studied.
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Lille Catholic University