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CompletedNCT02002026Updated Mar 16, 2016

Uterine Artery Ligation to Decrease Blood Loss With Central Placenta Previa

An interventional study of Uterine artery ligation in Placenta Previa Without Hemorrhage, sponsored by Minia Maternity University Hospital. Completed at 1 site in Egypt. Open to female participants aged 18 Years to 49 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2016-03-16.

Sponsored by Minia Maternity University Hospital · Not applicable, Interventional, and Prevention

Phase
Not applicable
Study type
Interventional
Enrollment
52
Allocation
Randomized
Ages
18 Years to 49 Years
Sex
Female
01

Study summary

This trial will address the effect of uterine artery ligation during Cesarean section in cases with placenta previa to decrease blood loss.

Read the detailed description

This Study will address the effect of uterine artery ligation prior to fetal delivery during Cesarean section in cases with central placenta previa to guard against postpartum hemorrhage and to minimize blood loss.

02

Conditions studied

  • Placenta Previa Without Hemorrhage

Keywords

  • placenta previa, uterine artery ligation
03

In context

Placenta Previa

93 studies on the registry are indexed under Placenta Previa; 20 are open to participants now.

This study's enrollment of 52 is below the median of 100 across 53 interventional studies indexed under Placenta Previa.

Browse Placenta Previa studies →

Lead sponsor

This is the only study on the registry with Minia Maternity University Hospital as lead sponsor.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 49 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes

Inclusion criteria

  • Placenta previa is diagnosed when the lowest placental edge is located within 5 cm of the internal os at ultrasound
  • Symptomatic Placenta previa with at least one episode of bleeding
  • Estimated gestational age within 28 to 40 weeks
  • Maternal age > 18 years
  • Informed consent
  • Social affiliation

Exclusion criteria

Exclusion Criteria:

  • Premature rupture of membranes
  • Severe bleeding.
  • Abnormal fetal heart rates.
  • Pre-eclampsia, chorioamnionitis, severe chronic renal disease.
05

Study design

Phase
Not applicable
Primary purpose
Prevention
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
52 participants (actual)

Study arms

  • Active comparator
    Ligation group

    Uterine artery ligation will be done for patients in this group

    Procedure: Uterine artery ligation

  • Placebo comparator
    Control group

    Conventional CS

    Procedure: Uterine artery ligation

Interventions

  • ProcedureUterine artery ligation

    Uterine artery ligation during cesarean section before delivery of the baby

06

What researchers measure

Primary outcomes

  1. Changes in hemoglobin level

    Changes in hemoglobin level before and after CS will reflect the amount of blood loss during operation

    Time frame: hemoglobin level will be done baseline and will be repeated 24 hours after delivery

Secondary outcomes

  1. Degree of uterine contractility.

    Time frame: During CS and within 3 hours after CS

07

Study locations

1 site
  • Minia Maternity University Hospital
    Minia, 61111, Egypt
08

References and documents

Publications

  • Sanad AS, Mahran AE, Aboulfotouh ME, Kamel HH, Mohammed HF, Bahaa HA, Elkateeb RR, Abdelazim AG, El-Din MAZ, Shawki HE. The effect of uterine artery ligation in patients with central placenta pevia: a randomized controlled trial. BMC Pregnancy Childbirth. 2018 Aug 29;18(1):351. doi: 10.1186/s12884-018-1989-5. PubMed 30157787 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 16, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT02002026
Lead sponsor
Minia Maternity University Hospital
Responsible party
Ahmad Sameer Sanad (Assistant Professor, Minia Maternity University Hospital) — Principal investigator
First posted
Dec 5, 2013
Start date
Nov 2013
Primary completion
Nov 2014
Completion
Nov 2014
Last update
Mar 16, 2016

Study contacts

Ahmad S Sameer, MD
principal investigator · Minia Maternity University Hospital

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Mar 2016. You cannot join it, but the record below documents what was studied.

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