An observational study in Osteoarthritis, sponsored by Parc Taulí Hospital Universitari. Status unknown at 1 site in Spain. Open to participants aged 50 Years to 81 Years. Per ClinicalTrials.gov, last updated 2013-11-25.
Sponsored by Parc Taulí Hospital Universitari · Observational
The purpose of this study is to determine the concentration of different adipocytokine (adiponectin, leptin, resistin, visfatin, osteopontin) and an inflammation classic markers as Interleukine 1 beta, tumor necrosis alfa, interleukine 6 and high sensibility reactive c protein in the synovial fluid of knee osteoarthritis patients, and compare with the inflammation detected with ultrasonography evaluation of the joint. In last years, some studies appeared focusing on the role of adipocytokines in osteoarthritis and they correlated adipocytokines with cartilage degradation and x-ray degree; in our study we will focused in the importance of adipocytokines in the inflammatory changes more than in joint destruction.
4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.
This study's planned enrollment of 35 is below the median of 100 across 791 observational studies indexed under Osteoarthritis.
Browse Osteoarthritis studies →Parc Taulí Hospital Universitari is the lead sponsor of 10 studies on the registry; 1 is open to participants now.
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Patient with knee osteoarthritis and synovial effusion who attende to a Rheumatologist unit for this problem. We made the visit and anonimously we kept the results of examination and ultrasonography in our database and we freezed synovial fluid. Now we will determine the adipocytokines and classic inflammatory parameters in this synovial fluid
Exclusion Criteria:
We recruited patients with osteoarthritis and synovial effusion to diagnostic the effusion and to confirm that this this synovial fluid had mechanical characteristics. Now we are going to determine the adipocytokines and traditional parameters of inflammation in this synovial fluid to correlate it, and we will associate it with the ultrasound explanation of the knee that we have in our database.
Other: arthrocentesis · Other: ultrasonography of the knee
The made a diagnostic arthrocentesis to all patient we included
We explored the affected knee with an ultrasound explanation in order to describe inflammatory changes based on standard examination.
Determination of adipocytokine levels (adiponectin, leptin, resistin, visfatin, osteopontin) in synovial fluid
We have all the synovial fluid freeze, so now we have to determine the levels of everyone.
Time frame: We determine adipocytoquines in one month, all patients in the same determination kit
Knee inflammation parameters detected by ultrasonography
We performed the ultrasonography evaluation at the same time than the visit were realized, and we have the results in a data base, so we will wait for the adipocytokine results and we will compare with ultrasound evaluation
Time frame: three months
To determine additional classic parameters of inflammation in synovial fluid as Interleukine 1 beta, Interleukine 6 and tumor necrosis factor alfa
We will use classic inflammation parameters to compare with adipocytokine levels
Time frame: We determine this inflammatory parameters in one month in all patient at the same time
This study is status unknown, as verified in Nov 2013. You cannot join it, but the record below documents what was studied.
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Parc Taulí Hospital Universitari