An interventional study of E-fied navigated rTMS and non-navigated rTMS in Tinnitus, sponsored by Turku University Hospital. Completed at 1 site in Finland. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2016-08-31.
Sponsored by Turku University Hospital · Not applicable, Interventional, and Treatment
Tinnitus is the perception of sound in the absence of corresponding external sound. Tinnitus affects approximately 10-15 % of the population. The prevalence increases with age and it is estimated that more than 20 % of the older people have tinnitus. Approximately 10-15 % of tinnitus patients have clinically relevant, disabling tinnitus causing for example anxiety, depression and sleep disturbances. The treatment of chronic tinnitus is difficult and most therapies focus on alleviating the condition rather than treating the cause. Pathophysiology of tinnitus still remains incompletely understood. Functional brain imaging data in tinnitus patients and animal models suggest that tinnitus is associated with increased neuronal activity, increased synchronicity, and functional reorganization within the auditory cortex either uni- or bilaterally, but there are also functional alterations in brain areas outside the auditory system. Transcranial magnetic stimulation (TMS) is a neuromodulation technique based on the principle of electromagnetic induction of an electric field in the brain by means of magnetic pulses given to the scalp. TMS is a non-invasive, painless, and safe method for modulation of cortical activity. TMS pulses given at low frequencies (≤ 1 Hz) have been shown to decrease cortical excitability both in experimental settings and humans, which forms the basis for using low frequency rTMS to treat chronic tinnitus patients, in whom hyperactivity of the auditory cortex has been observed in functional brain imaging studies
412 studies on the registry are indexed under Tinnitus; 87 are open to participants now.
This study's enrollment of 80 is above the median of 60 across 339 interventional studies indexed under Tinnitus.
Browse Tinnitus studies →Turku University Hospital is the lead sponsor of 280 studies on the registry; 65 are open to participants now.
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Exclusion Criteria:
Electrical field navigated transcranial magnetic stimulation
Device: E-fied navigated rTMS
Sham electrical field navigated rTMS
Device: sham E-field navigated rTMS
non-navigated rTMS
Device: non-navigated rTMS
Navigated rTMS,
Device: Navigated rTMS
1 hz on the superior temporal gyrus contralateral/left side with E-field navigated rTMS (Nexstim) targeted at the tonotopic representation area of the main frequency content of tinnitus
1 hz on the superior temporal gyrus contralateral/left side with non-navigated rTMS according to external landmarks (between T3/T4 and P3/P4 EEG-electrode locations)
1 hz on the left superior temporal gyrus with (MRI) navigated rTMS (Visor)
The change of loudness and pitch of the tinnitus is psychophysically measured, VAS questionnaires, Tinnitus Handicap Inventory, Tinnitus diary
Time frame: Change from baseline and 2-3 days after treatment period
This study is completed, as verified in Aug 2016. You cannot join it, but the record below documents what was studied.
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Turku University Hospital