An interventional study of Pregabalin and Placebo (for Pregabalin) in Pain, Postoperative and Hepatocellular Carcinoma, sponsored by Eastern Hepatobiliary Surgery Hospital. Completed at 1 site in China. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2016-03-31.
Sponsored by Eastern Hepatobiliary Surgery Hospital · Not applicable, Interventional, and Treatment
Pregabalin 150mg or placebo are administered 1 hour preoperatively in patients undergoing partial hepatectomy. Postoperatively, patients receive morphine as rescue analgesic. Morphine consumption in the first 48 hours is documented. Postoperative pain is measured by the visual analogue scale (VAS) score.
Methods: In this Randomized Controlled Trial, patients undergoing partial hepatectomy will be administered a single pre-operative dose of Pregabalin or a placebo. Primary endpoints are as follows:
6,741 studies on the registry are indexed under Carcinoma; 1,161 are open to participants now.
This study's enrollment of 40 is below the median of 45 across 5,170 interventional studies indexed under Carcinoma.
Browse Carcinoma studies →Eastern Hepatobiliary Surgery Hospital is the lead sponsor of 66 studies on the registry; 13 are open to participants now.
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Exclusion Criteria:
Single, 150 mg pre-operative oral dose of Pregabalin
Drug: Pregabalin
Single, placebo pre-operative dose
Drug: Placebo (for Pregabalin)
One 150 mg oral dose of Pregabalin given before surgery
Also known as: Lyrica
One oral dose of placebo given before surgery
Also known as: Sugar pill manufactured to mimic Pregabalin 150 mg tablet
Postoperative Opioid Consumption
Time frame: 48 hours
Postoperative Pain Scores on the Visual Analog Scale
Time frame: 24 hours
This study is completed, as verified in Mar 2016. You cannot join it, but the record below documents what was studied.
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Eastern Hepatobiliary Surgery Hospital