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CompletedNCT01919957MemO-EpiUpdated Sep 24, 2026

Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies

An observational study in Epilepsy, Unspecified, Pharmacologically Resistant and Memory Impairment, sponsored by Institut National de la Santé Et de la Recherche Médicale, France. Completed at 1 site in France. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-24.

Sponsored by Institut National de la Santé Et de la Recherche Médicale, France · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
29
Ages
18 Years and older
Sex
All
01

Study summary

This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies.

Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.

02

Conditions studied

  • Epilepsy, Unspecified, Pharmacologically Resistant
  • Memory Impairment

Keywords

  • epilepsy
  • surgery
  • functional MRI
  • memory outcome
03

In context

Epilepsy

1,805 studies on the registry are indexed under Epilepsy; 417 are open to participants now.

This study's enrollment of 29 is below the median of 102 across 521 observational studies indexed under Epilepsy.

Browse Epilepsy studies →

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France is the lead sponsor of 375 studies on the registry; 82 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

The research requires the inclusion of healthy volunteers (controls) and epileptic patients

Inclusion criteria

  • Patients with drug-resistant epilepsy
  • Age of 18 years or more
  • Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital
  • Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment
  • Covered by a social security system
  • Signing of consent form

Exclusion criteria

Exclusion Criteria:

  • Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom
  • Refusal to consent form
  • Contraindications to MRI
  • Pregnancy
  • Refusal to be informed in the case of detection of an abnormality during the experiment
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
29 participants (actual)
Patient registry
No

Groups and cohorts

  • memory outcome
06

What researchers measure

Primary outcomes

  1. Measure of successfull encoding

    Our goal is to define correlation between the measure of successfull object encoding trials (especially for binding) and the beta value activation in fMRI

    Time frame: 8 years

07

Study locations

1 site
  • INSERM - Plateau IRM du CENIR, CR-ICM Hôpital Pitié-Salpêtrière, 47/83 Boulevard de l'Hôpital
    Paris, 75651 Cedex 13, France
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 24, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01919957
Lead sponsor
Institut National de la Santé Et de la Recherche Médicale, France
Responsible party
Sponsor
First posted
Aug 9, 2013
Start date
Oct 10, 2013
Primary completion
Oct 9, 2021
Completion
Oct 9, 2022
Last update
Sep 24, 2026

Study contacts

Sophie Dupont, MD, PhD
principal investigator · Service de Soins de Suites et Réadaptation Neurologique, Hôpital de la Pitié-Salpêtrière, 47/83 Bd de l'Hôpital, 75651 Paris Cedex 13

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2025. You cannot join it, but the record below documents what was studied.

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