A Phase 1 interventional study of Lidocaine 1mg/kg and Lidocaine 1.5mg/kg in Etomidate Overdose of Undetermined Intent, sponsored by West China Hospital. Completed. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-08-05.
Sponsored by West China Hospital · Phase 1, Interventional, and Supportive care
IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.
The study was carried out in West China Hospital of Sichuan University, Chengdu, China. All the patients were informed in detail about the procedure and the medications they are going to get. Patients are well informed about the beneficial and possible hazards of the medicines and procedure. Patients are also informed that they can withdraw from the study at any time if they find it uncomfortable or harmful for them. Patients' written informed consent was obtained and registered for the permission from the Hospital's Ethics Board.
139 studies on the registry are indexed under Drug Overdose; 24 are open to participants now.
This study's enrollment of 100 is close to the median of 100 across 98 interventional studies indexed under Drug Overdose.
Browse Drug Overdose studies →West China Hospital is the lead sponsor of 483 studies on the registry; 240 are open to participants now.
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Exclusion Criteria:
0.9% Normal Saline is given instead of Lidocaine in the same volume and duration. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
Lidocaine 1mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
Drug: Lidocaine 1mg/kg
Lidocaine 1.5mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
Drug: Lidocaine 1.5mg/kg
Lidocaine 2mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
Drug: Lidocaine 2mg/kg
Lidocaine 2.5mg/kg is given intravenously within 2 minutes. Then, Etomidate 2mg intravenously every 15 seconds is given until the complete loss of consciousness as detected as the complete loss of eyelash reflex.
Drug: Lidocaine 2.5mg/kg
The total dosage of Etomidate needed for induction of anesthesia is recorded at last.
Also known as: Lidocaine, serial number:1303E11, Etomidate-Lipuro, serial number:11215033
same as other
Also known as: Lidocaine, serial number:1303E11, Etomidate-Lipuro, serial number:11215033
same as other
Also known as: Lidocaine, serial number:1303E11, Etomidate-Lipuro, serial number:11215033
same as other
Also known as: Lidocaine, serial number:1303E11, Etomidate-Lipuro, serial number:11215033
changes in blood pressure and heart rate.
Time frame: 6 weeks
No study locations are listed for this record.
This study is completed, as verified in Aug 2013. You cannot join it, but the record below documents what was studied.
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West China Hospital