An interventional study of Universal antibiotic prophylaxis and Screen-and-treat in Induced Abortion, Postaboral Pelvic Inflammatory Disease and Sexually Transmitted Infections, sponsored by The University of Hong Kong. Completed at 1 site in China. Open to female participants. Per ClinicalTrials.gov, last updated 2013-04-29.
Sponsored by The University of Hong Kong · Not applicable, Interventional, and Prevention
Screen-and-treat approach reduces postabortal pelvic inflammatory disease after induced abortion, and at the same time alters women's sexual behavior and prevents further re-infection by sexually transmitted infections when compared to the universal antibiotic prophylaxis strategy.
While universal antibiotic prophylaxis during induced abortion has been proven to reduce postabortal pelvic inflammatory diseases, screen-and-treat approach has the potential benefit of altering women's sexual behavior and preventing further re-infection by sexually transmitted infections. We conducted a randomized controlled trial to compare the effect of the two approaches in preventing postabortal pelvic inflammatory disease and the women's sexual behavior.
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Exclusion Criteria:
In the universal prophylaxis group, all women received doxycycline 100 mg twice daily for 7 days starting on the day of induced abortion. Screening for sexually transmitted diseases was done as baseline but the results were not revealed to the patients.
Drug: Universal antibiotic prophylaxis
In the screen-and-treat group, the results of screening for sexually transmitted infections (STI) were revealed to the patients. They would only receive appropriate specific antibiotics treatment only if they were screened positive for any of the STIs. If they were found to have STI, their sexual partners would also be referred to the local social hygiene clinics for contact tracing and treatment. Contraception by barrier methods would also be advised.
Other: Screen-and-treat
100 mg twice daily for 7 days starting on the day of induced abortion
Specific antibiotic treatment was only given if the women was found to have sexually transmitted infection(s) on screening.
Rate of postabortal inflammatory disease 6 weeks after induced abortion.
Time frame: 6 weeks after induced abortion.
Rate of re-infection by sexually transmitted infections 24 weeks after induced abortion.
Time frame: 24 weeks after induced abortion.
Proportion of women having abstinence from sexual intercourse or using condom at 6 weeks, 24 weeks and 1 year after induced abortion.
Time frame: 6 weeks, 24 weeks and 1 year after induced abortion
This study is completed, as verified in Apr 2013. You cannot join it, but the record below documents what was studied.
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The University of Hong Kong