An observational study in Acute Diverticulitis, sponsored by Herlev Hospital. Completed at 1 site in Denmark. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2014-02-25.
Sponsored by Herlev Hospital · Observational
The purpose of this study is to investigate sleep disturbances during Acute uncomplicated diverticulitis by polysomnography. The investigators hypothesis is the inflammation causes REM(rapid eye movement)-sleep reduction and this is correlated with plasma cytokine levels.
An increasing number of experimental studies have showed that inflammation can induce disturbances in sleep architecture, mediated by cytokines. Sleep is important both in health and disease processes and can affect recovery, morbidity and mortality.
Studies have been done on sleep disturbances after major and minor GI-surgery but never in relation to none surgical inflammatory diseases, namely acute diverticulitis.
This study will investigate sleep architecture by Polysomnography and inflammation by levels of pro inflammatory cytokines in plasma.
Following methods will be applied
Device: Polysomnograph - Embla Titanium (Natus Medical Incorporated, USA)
Procedure: Plasma cytokines (IL-2, IL-6 and TNF(tumor necrosis factor-alfa)
Procedure: Plasma CRP(C reactive protein) and leukocytes
146 studies on the registry are indexed under Diverticulitis; 26 are open to participants now.
This study's enrollment of 13 is below the median of 300 across 71 observational studies indexed under Diverticulitis.
Browse Diverticulitis studies →Herlev Hospital is the lead sponsor of 195 studies on the registry; 25 are open to participants now.
Counted across the registry records on this site, refreshed daily.
16 x Acute uncomplicated diverticulitis (Hansen and stock stage 1) patients aged 18-75 years managed by antibiotic treatment at Herlev Hospital.
Exclusion Criteria:
CT-verified acute uncomplicated diverticulitis managed by antibiotics
change in Sleep architecture during acute uncomplicated diverticulitis from baseline at the remission (30th day)
Sleep architecture measured by Polysomnography (awake, stadium I-IV, REM sleep, sleep latency, awakenings)
Time frame: 1st, 2nd and 30th nights following the admission
change in cytokine levels in plasma during the acute uncomplicated diverticulitis from baseline levels at remission
the Blood sample is taken prior to night sleep; Cytokines are measured by commercial ELISA-kits
Time frame: 1st, 2nd and 30th nights following the admission
change in CRP level in plasma during the acute uncomplicated diverticulitis from baseline levels at remission
the Blood sample is taken prior to night sleep; CRP is measured by standardized conventional method
Time frame: 1st, 2nd and 30th nights following the admission
change in leucocyte level in plasma during the acute uncomplicated diverticulitis from baseline levels at remission
the Blood sample is taken prior to night sleep; Leucocyte is measured by standardized conventional method
Time frame: 1st, 2nd and 30th nights following the admission
This study is completed, as verified in Feb 2014. You cannot join it, but the record below documents what was studied.
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Herlev Hospital