An observational study in Dyspnea, sponsored by University Hospital, Basel, Switzerland. Active, not recruiting at 2 sites in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-02-28.
Sponsored by University Hospital, Basel, Switzerland · Observational
To improve the diagnostic and prognostic utility of various biomarkers, detailed patient's history, physical examinations and technical devices in patients presenting with acute dyspnea.
Background: Acute heart failure is a common disease associated with high morbidity and mortality. Unfortunately, pathophysiology and optimal initial treatment are both ill defined.
Working Hypothesis:
Methods: This is a large multicenter center, observational study enrolling unselected, consecutive patients with acute dyspnea presenting to the Emergency Department. Patient history, physical examination and laboratory parameters will be systematically obtained. Echocardiographic examinations will be routinely performed. Follow-up will be done at specified intervals (3, 6 and 12 months) after the initial presentation and risk predictors will be analyzed in multivariable regression models.
Expected Value of the Proposed Project: The data obtained during this project will help to further improve diagnostics and prognostics in patients with acute dyspnea and to better understand underlying pathology of cardiac dysfunction in this cohort.
Significance: The study aims are up-to-date and deal with an important health care problem in society. Conclusions drawn will significantly change care of patients with acute heart failure probably leading to a significant reduction of rehospitalization, morbidity and mortality.
681 studies on the registry are indexed under Dyspnea; 159 are open to participants now.
This study's enrollment of 5,452 is above the median of 120 across 212 observational studies indexed under Dyspnea.
Browse Dyspnea studies →University Hospital, Basel, Switzerland is the lead sponsor of 989 studies on the registry; 191 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients presenting with acute dyspnea to the emergency department.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Diagnostic accuracy for the diagnosis of heart failure
Diagnostic of various biomarkers (such as natriuretic peptides, cardiac troponins, microRNA...), physical examination, detailed patient's history and novel technical devices.
Time frame: baseline
Prognostic utility in patients with dyspnea
Prognostic value of various biomarkers, echocardiography data and novel technical measurements regarding rehospitalisation, cardiovascular mortality and all-cause and mortality
Time frame: 360 days
Prognostic utility in patients with dyspnea
Prognostic value of various biomarkers, echocardiography data and novel technical measurements regarding rehospitalisation, cardiovascular mortality and all-cause and mortality
Time frame: 720 days
Ran from Apr 2006 to primary completion in Aug 2015, 112 months.
Of 105 non-industry observational studies under Dyspnea, half reached primary completion within 28 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 45. This study's 112 months is above that.
Counting every sponsor, half of 112 studies reached it within 27 months; a quarter within 10 and three quarters within 45.
How these figures are worked out, and which studies are left out of them.
This study is active, not recruiting, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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University Hospital, Basel, Switzerland →