Efficacy of Prophylactic Glycerin Suppositories for Feeding Intolerance in Very Low Birth Weight Preterm Infants: a Randomized Trial

Browse trials for

• Body Weight 1,223
• Birth Weight 445

Keywords

• Glycerin suppositories
• Feeding intolerance
• preterm infants
• prophylactic use
• elimination of meconium

Body Weight

1,223 studies on the registry are indexed under Body Weight; 131 are open to participants now.

This study's enrollment of 220 is above the median of 64 across 947 interventional studies indexed under Body Weight.

Lead sponsor

King Faisal Specialist Hospital & Research Center is the lead sponsor of 98 studies on the registry; 18 are open to participants now.

Study arms

• Experimental
  Intervention

  Intervention group will receive the glycerin suppository

  Drug: Glycerin suppositories

• No intervention
  Control

  Normal care

Interventions

• DrugGlycerin suppositories

Primary outcomes

1. days to achieve full tolerated feeding (breast milk or formula) by NGT or by mouth (140cc/kg/day)

   Time frame: 2years

Secondary outcomes

1. Incidence of feeding intolerance

   which is defined by the presence of GRVs \> 50 % of the previous feed for two consecutive feeds in addition to two of the following: I. Abdominal distention \> 1 cm in 12 hour. II. Abdominal tenderness. III. Vomiting. IV. Bile stained aspirate.

   Time frame: 2years

2. Incidence of necrotizing enterocolitis (NEC)

   Time frame: 2years