An interventional study of Strength Training and Aerobic Exercise in Osteoarthritis, sponsored by University Hospital, Akershus. Withdrawn at 1 site in Norway. Open to participants aged 45 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2020-01-14.
Sponsored by University Hospital, Akershus · Not applicable, Interventional, and Diagnostic
This study is the radiological component of an earlier registered trial under the title: Efficacy of Exercise on Physical Function and Cartilage Health in Patients With Knee Osteoarthritis. The main purpose in this component of the study is to evaluate the efficacy of aerobic exercise and strength training on the T2 and T1 rho relaxation times of the articular cartilage. It has been proven that exercise can improve function and reduce the need for analgesics in patients with osteoarthritis. With this study, we wish to investigate if different kinds of exercise can cause measurable improvements in T2 and T1 rho relaxation times of the articular cartilage, and also if this improvements are transient or permanent.
4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.
Browse Osteoarthritis studies →University Hospital, Akershus is the lead sponsor of 123 studies on the registry; 28 are open to participants now.
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Exclusion Criteria:
The strength group include progressive strength training and neuromuscular exercises. The inclusion will be performed 2-3 times a week for 12 weeks. Intervention: Other: Strength training
Other: Strength Training
The aerobic exercise group will cycle on an ergometer bicycle 2-3 times a week for 12 weeks on moderate loading. The loading will be controlled by a heart rate monitor and is defined as 85% of maximal heart rate.
Other: Aerobic Exercise
The control group will do as usual.
Qualitative Cartilage Morphology Assessment
Indirect cartilage morphology will by assessed by X-ray Direct cartilage morphology will be assessed by MRI morphometry The biochemical composition of the cartilage will be assessed by relaxometry (T2 and T1 rho relaxation times)
Time frame: One year
Semiquantitative Cartilage Assessment
Using semiquantitative techniques, the clinical manifestations of osteoarthritis assessed by MRI such as: cartilage lesions and bone marrow lesions will be assessed and quantified by MRI.
Time frame: One year
Plan to share: No
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This study is withdrawn, as verified in Jan 2020. You cannot join it, but the record below documents what was studied.
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University Hospital, Akershus