An interventional study of On-line hemodiafiltration and High-flux Hemodialysis in Sepsis and Acute Kidney Injury, sponsored by Chulalongkorn University. Completed at 1 site in Thailand. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2013-02-15.
Sponsored by Chulalongkorn University · Not applicable, Interventional, and Treatment
Following the concept of "peak concentration hypothesis", which suggest the cutting peak of pro- and anti-inflammatory mediators would result in restoring a situation of immunohomeostasis. The investigators conducted the prospective randomized controlled trial aimed to compare the clearance efficacy between on-line hemodiafiltration and high-flux hemodialysis in sepsis-related acute kidney injury patients. The lowering cytokines level during sepsis is postulated to improved outcomes in sepsis.
1,903 studies on the registry are indexed under Sepsis; 466 are open to participants now.
This study's enrollment of 28 is below the median of 105 across 899 interventional studies indexed under Sepsis.
Browse Sepsis studies →Chulalongkorn University is the lead sponsor of 313 studies on the registry; 60 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
On-line hemodiafiltration is a type of renal replacement therapy that was assigned as the intervention to compare with the control arm
Procedure: On-line hemodiafiltration
The standard high-flux hemodialysis is the routine renal replacement therapy in sepsis-related acute kidney injury patients and is assigned as the intervention for the control group.
Procedure: High-flux Hemodialysis
pre-dilution 40% of blood flow rate blood flow rate 300-350 ml/min dialysate flow rate 800 ml/min
Also known as: Nikkiso dialysis machine, ARROW dual lumen dialysis catheter, PureFlux -150H synthetic membrane dialyzer
blood flow rate 300-350 ml/min dialysate flow rate 800 ml/min
Reduction in plasma Vascular Endothelial Growth Factor (VEGF)level
Time frame: At time 0-hour and 4-hour of the study dialysis session
Intradialytic hypotension
Time frame: During 4 hours of the study dialysis session
Renal recovery (at 30 days)
Time frame: participants will be followed for the renal recovery (dialysis-free) for the 30 days from the first initiation of dialysis
Hospital patient mortality
mortality during hospital admission
Time frame: participants will be followed for the duration of hospital stay (an expected average of 5 weeks)
This study is completed, as verified in Feb 2013. You cannot join it, but the record below documents what was studied.
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Chulalongkorn University