An observational study in Obesity, sponsored by Karolinska Institutet. Completed at 3 sites in Sweden. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2020-02-28.
Sponsored by Karolinska Institutet · Observational
There is a variability in weight loss after gastric bypass surgery for obesity despite a standardised surgical procedure. This study aims to investigate if genetic markers can predict outcome after gastric by-pass surgery in treatment of obesity. The investigators will also study if adenovirus infection can influence the outcome after surgery. In a subgroup of patients, hormonal changes after gastric by-pass surgery will be assessed. Lipid and protein patterns will be assessed in plasma and tissues. Omental and subcutaneous fat as well as liver biopsies and whole blood are stored in a biobank. The same tissues will be collected from non-obese controls undergoing gallbladder surgery.
1,766 studies on the registry are indexed under Weight Loss; 277 are open to participants now.
This study's enrollment of 2,000 is above the median of 92 across 219 observational studies indexed under Weight Loss.
Browse Weight Loss studies →Karolinska Institutet is the lead sponsor of 1,113 studies on the registry; 267 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Obesity
Exclusion Criteria:
Gastric bypass surgery and non-obese controls undergoing cholecystectomy
Procedure: Gastric bypass or cholecystectomy
Genetic markers
Blood samples and tissue biopsies taken at the time of surgery and at follow-up.
Time frame: day of surgery and 1 and 2 years after surgery
Lipid and protein patterns in plasma and tissues
Blood samples taken and tissue biopsies taken at the time of surgery and at follow-up
Time frame: day of surgery and at 1 and 2 years postoperatively
Previous viral infection
Blood samples taken before surgery
Time frame: At time of surgery
Genexpression and comorbid disease
Gene expression studies in tissue biopsies and whole blood at time of surgery and follow-up
Time frame: At time of bariatric surgery and 1-2 years postoperatively
This study is completed, as verified in Feb 2020. You cannot join it, but the record below documents what was studied.
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Karolinska Institutet