An interventional study of E. coli endotoxin, US standard in Febrile Illness Acute, Inflammation and Metabolic Diseases, sponsored by University of Aarhus. Completed at 1 site in Denmark. Open to male participants aged 25 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-11-13.
Sponsored by University of Aarhus · Not applicable, Interventional, and Treatment
The purpose of the study is to investigate the metabolic effects during acute inflammation with and without the nutritional supplement of amino acids.
E. Coli Endotoxin (LPS, lipopolysaccharide) is used to initiate an inflammatory response.
The study is an interventional randomized placebo study including 8 healthy male subjects. Each subject participates 3 times (different days) and are given one of following interventions:
It is our hypothesis that the nutritional intervention during acute inflammation plays an important role in lipid and protein metabolism.
997 studies on the registry are indexed under Metabolic Diseases; 234 are open to participants now.
This study's enrollment of 8 is below the median of 48 across 670 interventional studies indexed under Metabolic Diseases.
Browse Metabolic Diseases studies →University of Aarhus is the lead sponsor of 1,274 studies on the registry; 183 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Only saline is given.
Endotoxin is given + Placebo (Saline)
Biological: E. coli endotoxin, US standard
Endotoxin is given + amino acids (intravenously)
Biological: E. coli endotoxin, US standard
Protein catabolism during acute illness
Protein catabolism is measured with amino acid tracer techniques comparing radioactive marked amino acids from blood samples.
Time frame: After 6 hours intervention
The local effects on muscle and fat tissue
A muscle + fat biopsy are taken twice during the intervention to focus on the local effects in these tissues.
Time frame: At 2 hours and 4,5 hours
Other systemic metabolic effects during acute illness
Lipid and glucose metabolism are measured with tracer techniques with radioactive marked glucose + lipid.
Time frame: 6 hours
This study is completed, as verified in Nov 2014. You cannot join it, but the record below documents what was studied.
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University of Aarhus