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CompletedNCT01702779HiFloLUSUpdated Dec 2, 2014

Nasal Humidified High Flow Oxygen During Weaning From Mechanical Ventilation : Ultrasonography Study

An interventional study of mechanical ventilation and mechanical ventilation in Adult Patients Ventilated More Than 48 h, Stable Respiratory and Hemodynamic Conditions for SBT and Consent of Patients, sponsored by University Hospital, Clermont-Ferrand. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2014-12-02.

Sponsored by University Hospital, Clermont-Ferrand · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
80
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

This is a prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

Read the detailed description

Prospective randomized clinical multicentric study on ICU (Intensive Care University) comparing nasal humidified high flow therapy versus standard oxygen with Lung Ultrasound Score during weaning from mechanical ventilation

02

Conditions studied

  • Adult Patients Ventilated More Than 48 h
  • Stable Respiratory and Hemodynamic Conditions for SBT
  • Consent of Patients
  • Arterial Line

Keywords

  • Weaning from mechanical ventilation
  • Lung ultrasound
  • Oxygen inhalation therapy
03

In context

Lead sponsor

University Hospital, Clermont-Ferrand is the lead sponsor of 841 studies on the registry; 178 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Adult patients ventilated more than 48 h
  • Stable respiratory and hemodynamic conditions for SBT
  • Consent of patients
  • Arterial line

Exclusion criteria

Exclusion Criteria:

  • COBP
  • Laryngeal dyspnea
  • Tracheostomy
  • Arythmya
  • No echogenicity
  • Paraplegia >T8
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
80 participants (actual)

Study arms

  • Other
    optiflow

    Other: mechanical ventilation

  • Other
    O2

    Other: mechanical ventilation

Interventions

  • Othermechanical ventilation

    Prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

  • Othermechanical ventilation

    Prospective, randomized clinical multicentric study in ICU (Intensive Care University)during weaning from mechanical ventilation.

06

What researchers measure

Primary outcomes

  1. variations of lung ultrasound score

    Time frame: 24 hours after extubation

Secondary outcomes

  1. Lung ultrasound score

    Time frame: at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation

  2. rates of patients with postextubation distress

    Time frame: during the 48th post-extubation

  3. Electrical Impedance tomography

    Time frame: at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation

  4. Epithelial and endothelial biomarkers

    Time frame: at baseline, 4-6 hours after extubation, 24 hours after extubation, 48 hours after extubation

07

Study locations

1 site
  • CHU Clermont-Ferrand
    Clermont-Ferrand, France
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 2, 2014, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01702779
Lead sponsor
University Hospital, Clermont-Ferrand
Collaborators
Pitié-Salpêtrière Hospital
Responsible party
Sponsor
First posted
Oct 8, 2012
Start date
Aug 2011
Primary completion
Jun 2013
Completion
Jun 2013
Last update
Dec 2, 2014

Study contacts

Sébastien PERBET
principal investigator · University Hospital, Clermont-Ferrand
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2014. You cannot join it, but the record below documents what was studied.

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