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CompletedNCT01686984Updated May 14, 2015

Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease

An interventional study of Altered breath in Pulmonary Gas Exchange and Carbon Dioxide, sponsored by Region Skane. Completed at 1 site in Sweden. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2015-05-14.

Sponsored by Region Skane · Not applicable, Interventional, and Basic science

Phase
Not applicable
Study type
Interventional
Enrollment
8
Allocation
Not applicable
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of this study is to investigate how inspiratory flow pattern influences CO2 elimination in people without primary lung disease.

The hypothesis is that a long mean distribution time, caused by a long postinspiratory pause and high end-inspiratory flow, will promote CO2 exchange in the alveoli.

02

Conditions studied

  • Pulmonary Gas Exchange
  • Carbon Dioxide

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03

In context

Lung Diseases

3,303 studies on the registry are indexed under Lung Diseases; 355 are open to participants now.

This study's enrollment of 8 is below the median of 72 across 2,118 interventional studies indexed under Lung Diseases.

Browse Lung Diseases studies →

Lead sponsor

Region Skane is the lead sponsor of 372 studies on the registry; 113 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • No known primary lung disease

Exclusion criteria

Exclusion Criteria:

  • Primary lung disease
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrollment
8 participants (actual)

Study arms

  • Experimental
    Altered breath

    The group where the investigators alter the inspiratory and expiratory aspects of a ventilated breath.

    Other: Altered breath

Interventions

  • OtherAltered breath
06

What researchers measure

Primary outcomes

  1. Carbon dioxide elimination in a ventilator assisted breath.

    Time frame: 30 minutes

Secondary outcomes

  1. Blood CO2 concentration.

    Time frame: 30 minutes

07

Study locations

1 site
  • Division of Brain, Heart and Lungs, Neurosurgical Clinic, Skane University Hospital, Lund
    Lund, Skane 22185, Sweden
08

References and documents

Publications

  • Sturesson LW, Malmkvist G, Allvin S, Collryd M, Bodelsson M, Jonson B. An appropriate inspiratory flow pattern can enhance CO2 exchange, facilitating protective ventilation of healthy lungs. Br J Anaesth. 2016 Aug;117(2):243-9. doi: 10.1093/bja/aew194. PubMed 27440637 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 14, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01686984
Lead sponsor
Region Skane
Responsible party
Sponsor
First posted
Sep 18, 2012
Start date
Sep 2012
Primary completion
May 2015
Completion
May 2015
Last update
May 14, 2015

Study contacts

Mikael Bodelsson, Professor
principal investigator · Division of Anesthesia, Skane University Hospital, Lund, Sweden

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2015. You cannot join it, but the record below documents what was studied.

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