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CompletedNCT01669005MedIsoUpdated Aug 20, 2012

The Utility of Multiplex PCR for Detection of DNA in Neutropenic Patients With Hematological Malignancies

An observational study in Neutropenia, sponsored by Centre Hospitalier Universitaire Vaudois. Completed. Per ClinicalTrials.gov, last updated 2012-08-20.

Sponsored by Centre Hospitalier Universitaire Vaudois · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
84
Sex
All
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Study summary

Objectives: Invasive infections are the leading cause of morbidity and mortality in patients treated for hematological malignancies. Blood cultures are often negative in neutropenic patients because of low-burden of organisms, previous antibiotic therapy or non-infectious reason of fever. More rapid, accurate and sensitive diagnostic tools are needed.

Hypothesis: Multiplex real-time PCR may detect microbial DNA in neutropenic patients before febrile episode. To investigate this hypothesis, EDTA-blood was routinely collected for multiplex PCR at admission and 3x/week thereafter until discharge or recovery from neutropenia

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Conditions studied

  • Neutropenia

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Keywords

  • neutropenia
  • multiplex PCR
  • infection
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In context

Neutropenia

396 studies on the registry are indexed under Neutropenia; 57 are open to participants now.

This study's enrollment of 84 is below the median of 175 across 96 observational studies indexed under Neutropenia.

Browse Neutropenia studies →

Lead sponsor

Centre Hospitalier Universitaire Vaudois is the lead sponsor of 203 studies on the registry; 47 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Patients hospitalized in the bone marrow transplant unit in the study period

Inclusion criteria

  • patients aged ≥18 years
  • autologous or allogeneic hematopoietic stem cells transplantation or induction/consolidation chemotherapy performed

Exclusion criteria

Exclusion Criteria:

  • No blood samples were taken
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
84 participants (actual)
Biospecimen retention
Samples with dna

Groups and cohorts

  • Bone marrow transplant unit patients

    hospitalized patients in the bone marrow transplant unit for an autologous or allogeneic hematopoietic stem cells transplantation or induction/consolidation chemotherapy

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Study locations

No study locations are listed for this record.

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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 20, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01669005
Lead sponsor
Centre Hospitalier Universitaire Vaudois
Collaborators
University Hospital, Basel, Switzerland
Responsible party
Andrej Trampuz (MD, Centre Hospitalier Universitaire Vaudois) — Principal investigator
First posted
Aug 20, 2012
Start date
Nov 2007
Primary completion
Dec 2008
Completion
Dec 2008
Last update
Aug 20, 2012

Study contacts

Andrej Trampuz, MD
study director · University Hospital Lausanne, Switzerland
Christina Orasch, MD
principal investigator · University Hospital Lausanne, Switzerland

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2012. You cannot join it, but the record below documents what was studied.

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