An observational study in Penicillin Allergy, Aminopenicillin Allergy and Beta Lactam Adverse Reaction, sponsored by Chulalongkorn University. Completed at 1 site in Thailand. Open to participants aged 7 Years and older. Per ClinicalTrials.gov, last updated 2019-10-29.
Sponsored by Chulalongkorn University · Observational
The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity will be determined by using commercially available standard skin test reagents and the diagnostic agents available in Thailand. We hypothesize that only minority of patients with such a history are truly allergic.
Patients with a history of beta-lactam hypersensitivity will be evaluated by the standard skin test reagents (major and minor determinants of penicillin, amoxicillin, and clavulanic if applicable), and intravenous forms of beta-lactam antibiotics .
Diagnostic values of the measurement of specific Immunoglobulin E to penicillin/aminopenicillin and skin test reagents currently available in Thailand will be comparatively analyzed with the standard skin test reagents.
The measurement of drug-induced interferon-gamma releasing cells will be measured in patients with a history of non-immediate reaction.
1,916 studies on the registry are indexed under Hypersensitivity; 265 are open to participants now.
This study's enrollment of 500 is above the median of 115 across 479 observational studies indexed under Hypersensitivity.
Browse Hypersensitivity studies →Chulalongkorn University is the lead sponsor of 312 studies on the registry; 59 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients with a history of beta-lactam hypersensitivity
Exclusion Criteria:
Patients with a history of hypersensitivity reaction to beta-lactam antibiotics
The true prevalence of drug allergy in patients with a history of beta-lactam hypersensitivity
The skin test positive rate in patients with a history of beta-lactam hypersensitivity
Time frame: 1 year
Clinical values of various diagnostic modalities in patients with a history of beta-lactam hypersensitivity
The diagnostic values of skin testing, drug-specific Immunoglobulin E measurement, and interferon-gamma ELISpot assay for the diagnosis of beta-lactam hypersensitivity
Time frame: 1 year
Plan to share: No
This study is completed, as verified in Oct 2019. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Chulalongkorn University