A Phase 4 interventional study of conventional dose epinephrine and low dose epinephrine in Croup and Epinephrine, Administration, Inhalation, sponsored by Seoul National University Hospital. Status unknown at 1 site in Korea, Republic of. Open to participants aged 6 Months to 5 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-01-09.
Sponsored by Seoul National University Hospital · Phase 4, Interventional, and Treatment
Croup is common illness presenting emergency department with dyspnea. The main treatment for croup is nebulized L-epinephrine and steroid. The study for the dose of nebulized L-epinephrine is restricted that the study of comparision between racemic epinephrine and L-epinephrine.
The investigators conducted this study to compare the effectiveness of low dose L-epinephrine with conventional dose L-epinephrine.
18 studies on the registry are indexed under Croup; 2 are open to participants now.
This study's planned enrollment of 84 is close to the median of 86 across 12 interventional studies indexed under Croup.
Browse Croup studies →Seoul National University Hospital is the lead sponsor of 1,900 studies on the registry; 274 are open to participants now.
Of its 12 completed or terminated interventional studies of FDA-regulated products, 2 (17%) have results posted.
Counted across the registry records on this site, refreshed daily.
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Exclusion Criteria:
L-epinephrine (1:1000) 0.5 mL/kg (maximum 5mL) + normal saline : total 5mL
Drug: conventional dose epinephrine
L-epinephrine (1:1000) 0.1 mL/kg (maximum 1mL) + normal saline : total 5mL
Drug: low dose epinephrine
conventional dose epinephrine : 0.5mg/kg + 0.9% normal saline
low dose epineprhine : 0.1mg/kg + 0.9% normal saline
the difference of Westley croup score between baseline and 30 minutes after neublized treatment
Time frame: 30 minutes
the incidence of use of additional neublized treatment
Time frame: 30 minutes
Westley croup score
Time frame: 30, 60, 90, 120, 180, 240 minutes
the side effect of epinephrine
Hypertension, tachycardia : more than 95th percentile for age Arrythmia Pallor Tremor
Time frame: participants will be followed for the duration of ED stay
respiratory rate, oxygen saturation
Time frame: 30, 60, 90, 120, 180, 240 minutes
health care utilization- length of stay in emergency department, admission rate, revisit dut to croup symptom
Time frame: within 7 days
treatment failure
after additional nebulized epineprhine at 30 minutes, as the croup scrore is higher than baselin, the blinding is cleared.
Time frame: 30min after 2nd epinephrine nebulizer
rebound effect
the croup score is the same or over than the base line
Time frame: 180 minutes
This study is status unknown, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Epinephrine
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