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CompletedNCT01635699Updated Jul 9, 2012

Effect of Modified Fujita Technique Uvulopalatoplasty on Oxidative DNA Damage Levels in Patients With Obstructive Sleep Apnea SyndromE (OSAS)

An observational study in Sleep Apnea, Obstructive, sponsored by Erzurum Regional Training & Research Hospital. Completed at 1 site in Turkey. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2012-07-09.

Sponsored by Erzurum Regional Training & Research Hospital · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
49
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of this study is to determine the possible effects of uvulopalatopharngoplasty (UPPP) -which is a a therapy used on patients with Obstructive sleep apnea syndrome (OSAS- on oxidative damage.

Read the detailed description

Obstructive sleep apnea syndrome (OSAS) is a sydrome which has characteristic upper way obstruction and a decrease in blood oxygen saturation as sleeping. uvulopalatopharngoplasty (UPPP)is one of the surgical approaches applied to the patients with OSAS, since the oxidative damage markers have been found high in patients with OSAS. Although antioxidant levels were higher in patients with OSAS than those in normal population, there is report about the effect of UPPP on antioxidant status in patients with OSAS. We performed this study to confirm whether is there a We performed the present study to confirm whether there is a relationship between the OSAS and oxidative damage before and after UPPP.

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Conditions studied

  • Sleep Apnea, Obstructive

Keywords

  • DNA oxidation
  • obstructive sleep apnea
  • lipid peroxidation
  • oxidative stresses
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In context

Apnea

1,422 studies on the registry are indexed under Apnea; 160 are open to participants now.

This study's enrollment of 49 is below the median of 106 across 386 observational studies indexed under Apnea.

Browse Apnea studies →

Lead sponsor

Erzurum Regional Training & Research Hospital is the lead sponsor of 11 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients who underwent uvulopalatopharngoplasty (UPPP)for Obstructive sleep apnea syndrome (OSAS) at the otolaryngology department of our hospital in Erzurum, Turkey.

Inclusion criteria

  • Patients who underwent uvulopalatopharngoplasty (UPPP)for Obstructive sleep apnea syndrome (OSAS)

Exclusion criteria

Exclusion Criteria:

  • Anormal nasopharyngeal computed tomography, chronic diseases such as diabetes mellitus, hypertension etc.
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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
49 participants (actual)
Biospecimen retention
Samples without dna
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Study locations

1 site
  • Erzurum Regional Educational Researh Hospital
    Erzurum, 25000, Turkey
07

References and documents

Publications

  • Bakan E, Fidan V, Alp HH, Baygutalp NK, Cokluk E. Effect of Modified Fujita Technique Uvulopalatoplasty on Oxidative DNA Damage Levels in Patients With Obstructive Sleep Apnea Syndrome. J Craniofac Surg. 2015 Jul;26(5):e392-6. doi: 10.1097/SCS.0000000000001870. PubMed 26163849 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 9, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01635699
Lead sponsor
Erzurum Regional Training & Research Hospital
Responsible party
Vural Fidan (operating surgeon doctor, Erzurum Regional Training & Research Hospital) — Principal investigator
First posted
Jul 9, 2012
Start date
Jun 2008
Primary completion
Jun 2008
Completion
Mar 2011
Last update
Jul 9, 2012

Study contacts

vural fidan, operating surgeon doctor
principal investigator · eskisehir yunus emre state hospital (still works here)

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 2012. You cannot join it, but the record below documents what was studied.

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