An interventional study of Protein intake. in Healthy Females and Protein Requirement, sponsored by The Hospital for Sick Children. Completed at 1 site in Canada. Open to female participants aged 76 Years to 90 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-01-09.
Sponsored by The Hospital for Sick Children · Not applicable, Interventional, and Treatment
Minimal data are available on protein requirements throughout the lifespan. Currently available recommendations are based on nitrogen balance data. The limitations of the nitrogen balance method have been well described. Importantly, nitrogen balanced underestimates requirements.
The current DRI requirement for healthy adult males is based on the reanalysis of the nitrogen balance date from Young and Scrimshaw. This data was reanalyzed statistically by Rand et al. and he concluded that the protein requirement of healthy adults was 0.65 and 0.83 (mean and RDA) g/kg/day of good quality protein. Using IAAO, the investigators group estimated the protein requirement of young men (mean age 27 years) to be 0.93 and 1.2 g/kg/day (mean and RDA).
Currently there are no studies on protein requirement in the elderly. In a recent nutrition survey conducted by NHANES, the authors concluded that adults between the ages of 51 - 70 years old consumed an average on 1.0 g/kg/day (ideal body weight) of protein which represents about 15 % of calories. Depending on the calculations used for ideal body weight some older adults could be getting higher or lower than requirement. There is no scientifically derived protein estimate for older adults. Therefore there is a need to measurer protein requirement in that population.
The goal of this study therefore is to measure the protein requirement of female elderly subjects >75 years using the IAAO technique.
The Hospital for Sick Children is the lead sponsor of 568 studies on the registry; 81 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
subjects will recieve differnt levels of protein intakes varying from 0.2 to2.0g/kg/day.
Dietary Supplement: Protein intake.
protein intakes will be varied at 0.2, 0.5, 0.7, 0.9, 1.0, 1.2, 1.5, 1.8 and 2.0g/kg/day
13CO2 Production
Urine and breath samples will be collected on day 3 of the experiment to determine the rate of production
Time frame: Study Day 3
This study is completed, as verified in Jan 2018. You cannot join it, but the record below documents what was studied.
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