CClinicalTrials.gg
Status unknownNCT01599845NanoexposureUpdated May 16, 2012

The Differential Pattern of Deposition of Nano Particles in the Airways of Exposed Workers

An observational study in Inadequate or Impaired Respiratory Function, sponsored by Tel-Aviv Sourasky Medical Center. Status unknown. Open to participants aged 20 Years to 60 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-05-16.

Sponsored by Tel-Aviv Sourasky Medical Center · Observational

The sponsor has not verified this record recently (last verified May 2012), so the status shown — last known as Not yet recruiting — may be out of date.
Study type
Observational
Model
Case-only
Time perspective
Cross-sectional
Enrollment
60
Ages
20 Years to 60 Years
Sex
All
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Study summary

Investigation of the differences between the levels of extracellular and intracellular nano-particles in workers exposed to environmental particles during their employment to enhance understanding the process of penetration of the particles to respiratory epithelial cells.

Read the detailed description

This study investigates the following questions:

Does occupational exposure to nanoparticles influence permeation of such particles to respiratory airways? Is there a correlation between the levels of nanoparticles in sample biological fluids of the patients and their pulmonary functions.

Is there a correlation between the levels of nanoparticles in sample biological fluids of the patients and respiratory tract infections.

The study protocol includes the following steps:

Initial interview of the patient Measurement of nanoparticles in samples of exhaled breath condensate using NanoSight LM 20 Measurement of nanoparticles in induced sputum. And finally examination of the relationship between the measured parameters and the indices of pulmonary infection, and pulmonary function as measured by the pulmonary department of the TASMC.

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Conditions studied

  • Inadequate or Impaired Respiratory Function

Keywords

  • Lung
  • Alveoli
  • Nanoparticles
  • Particulate matter
  • Exhaled breath condensate
  • Induced sputum
  • Forced expiratory volume
  • Force vital capacity
03

In context

Respiratory Insufficiency

1,650 studies on the registry are indexed under Respiratory Insufficiency; 296 are open to participants now.

This study's planned enrollment of 60 is below the median of 100 across 545 observational studies indexed under Respiratory Insufficiency.

Browse Respiratory Insufficiency studies →

Lead sponsor

Tel-Aviv Sourasky Medical Center is the lead sponsor of 541 studies on the registry; 49 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
20 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Patients

Inclusion criteria

  • Adults over 20 years of age who visit Ichilov Hospital for medical complaints/inquiries regarding respiratory tract.
  • Study population is composed of people who are exposed to environmental particles form industrial sources.
  • Informed consent is requested from each subject.

Exclusion criteria

Exclusion Criteria:

  • Unemployed individuals.
  • Individuals who are not working in industrial jobs, such as office workers and secretaries.
05

Study design

Observational model
Case-only
Time perspective
Cross-sectional
Enrollment
60 participants (estimated)

Groups and cohorts

  • Nanoparticle exposed
06

What researchers measure

Primary outcomes

  1. Analysis of the size distribution of nano-particles in exhaled breath condensate

    Each subject will be examined once. The total time for collection of data is estimated as about one year.

    Time frame: One year

07

Study locations

No study locations are listed for this record.

08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 16, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01599845
Lead sponsor
Tel-Aviv Sourasky Medical Center
Responsible party
Sponsor
First posted
May 16, 2012
Start date
May 2012
Primary completion
Dec 2012 (estimated)
Completion
May 2013 (estimated)
Last update
May 16, 2012

Study contacts

Yehuda Schwarz, M.D.
Contact
schwarz.reot@gmail.com
03-6973774
Yehuda Schwarz, M.D.
principal investigator · Tel Aviv Sourasky Medical Center (TASMC, Ichilov)

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in May 2012. You cannot join it, but the record below documents what was studied.

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