An interventional study of Partial Rebreathing Mask in Hyperventilation, Chronic Idiopathic Hyperventilation and Dysfunctional Breathing, sponsored by University of Aarhus. Completed at 1 site in Denmark. Open to participants aged 18 Years to 70 Years. Per ClinicalTrials.gov, last updated 2016-05-19.
Sponsored by University of Aarhus · Not applicable, Interventional, and Treatment
Background: Chronic Idiopathic Hyperventilation (CIH) is a form of dysfunctional breathing which has proven hard to treat effectively. The investigators hypothesised that by periodically inducing normocapnia over several weeks, it would be possible to raise the normal resting level/set point of CO2 and achieve a reduction of symptoms.
Methods: Six CIH patients were treated two hours a day for four weeks with a novel breathing mask. The mask was used to induce normocapnia in these chronically hypocapnic patients.
Capillary blood gases (PcCO2, pH, Standard Base Excess (SBE) etc.) were measured at baseline and once each week at least three hours after mask use, as well as spirometric values, breath holding tolerance and hyperventilation symptoms as per the Nijmegen Questionnaire (NQ),.
43 studies on the registry are indexed under Hyperventilation; 6 are open to participants now.
This study's enrollment of 6 is below the median of 40 across 31 interventional studies indexed under Hyperventilation.
Browse Hyperventilation studies →University of Aarhus is the lead sponsor of 1,300 studies on the registry; 189 are open to participants now.
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Chronic idiopathic hyperventilation, i.e.:
Exclusion Criteria:
A novel membrane breathing mask which facilitates a partial rebreathing of expired gas (thereby raising systemic CO2), while allowing a diffusion of oxygen from the atmosphere to the user, through the membranes.
Device: Partial Rebreathing Mask
Inducing normal CO2 for two hours a day for four weeks
Also known as: CDA mask, Balancair Mask
Blood gas and acid/base status
pH, PCO2, PO2, Standard Base Excess
Time frame: Once every week in the treatment period of four weeks
Hyperventilation symptoms
Nijmegen Questionnaire
Time frame: once a week
Breath Hold Tolerance
Time frame: once a week
Spirometric values
FEV1, FVC
Time frame: once a week
This study is completed, as verified in May 2016. You cannot join it, but the record below documents what was studied.
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