A Phase 4 interventional study of 0.75% ropivacaine concentration and 0.375% ropivacaine concentration in Epidural Anesthesia, Ropivacaine Concentration and Hemodynamics, sponsored by Pusan National University Hospital. Completed at 1 site in Korea, Republic of. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2017-08-29.
Sponsored by Pusan National University Hospital · Phase 4, Interventional, and Basic science
In this trial, the investigators intend to examine whether the concentration of local anesthetics during epidural analgesia could be modulating factor for change of hemodynamics in patients undergoing major upper abdominal surgery.
One hundred and twenty patients scheduled for major abdominal surgery under TEA combined general anesthesia were randomized in a double-blinded method to receive one of three different concentration study solutions in 8 ml of volume after the induction of anesthesia: 0.75% ropivacaine (60 mg), 0.375% ropivacaine (30 mg), or 0.2% ropivacane (16 mg).
In each group, the patients were divided into two subgroups at the age of 60 to perform age based analysis. The acquired hemodynamic data after administration of epidural loading dose were compared and analyzed between young and elderly groups in each group.
Pusan National University Hospital is the lead sponsor of 78 studies on the registry; 8 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Inclusion Criteria: all of the followings needed.
Exclusion Criteria:
0.375% ropivacaine 8ml was injected epidurally after induction of general anesthesia
Drug: 0.375% ropivacaine concentration
0.75% ropivacaine 8ml was injected epidurally after induction of general anesthesia
Drug: 0.75% ropivacaine concentration
0.2% ropivacaine 8ml was injected epidurally after induction of general anesthesia
Drug: 0.2% ropivacaine concentration
0.75% ropivacaine 8ml was injected epidurally after induction of general anesthesia
0.375% ropivacaine 8ml was injected epidurally after induction of general anesthesia
0.2% ropivacaine 8ml was injected epidurally after induction of general anesthesia
hemodynamic changes depends on the concentration of ropivacaine
Systolic blood pressure, diastolic blood pressure, MAP, HR, stroke volume, stroke volume, stroke volume index, stroke volume variation, cardiac output, and cardiac index were continuously measured at 5 minute intervals during 1 hour.
Time frame: during 1hour after administration of epidural drug dosing
Age based hemodynamic changes depends on the concentration of ropivacaine
In each group, the patients were divided into two subgroups at the age of 60 to perform age based analysis. The acquired hemodynamic data after administration of epidural loading dose were compared and analyzed between young and elderly groups in each group. Systolic blood pressure, diastolic blood pressure, MAP, HR, stroke volume, stroke volume, stroke volume index, stroke volume variation, cardiac output, and cardiac index were continuously measured at 5 minute intervals during 1 hour.
Time frame: during 1hour after administration of epidural drug dosing
This study is completed, as verified in Aug 2017. You cannot join it, but the record below documents what was studied.
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Pusan National University Hospital