An interventional study of High daidzein supplement and High genistein supplement in Postmenopause, sponsored by Wageningen University. Completed at 1 site in Netherlands. Open to female participants aged 50 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-10-31.
Sponsored by Wageningen University · Not applicable and Interventional
Alleged benefits experienced after the consumption of soy in Asian countries have been attributed to the isoflavone content of soy products. Amongst other benefits, isoflavones are believed to relieve menopausal symptoms and are therefore often consumed in supplement form in Western countries. These supplements contain relatively high amounts of isoflavones and are on the market in different compositions. The question is whether supplements with different compositions exert similar effects or whether the effects differ substantially.
Intervention study with two substudies; each substudy is a double blind placebo controlled crossover intervention study. The first substudy has two groups: 'high daidzein' supplement versus placebo (n=18) and vice versa (n=18); the second substudy also has two groups 'high genistein' versus placebo (n=18) and vice versa (n=18).
Wageningen University is the lead sponsor of 150 studies on the registry; 15 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Dietary Supplement: High daidzein supplement · Dietary Supplement: High genistein supplement
Dietary Supplement: High daidzein supplement · Dietary Supplement: High genistein supplement
8 weeks exposure to the supplement, daily 100 mg of isoflavones
Also known as: Phyto soya forte - Arkpharma
8 weeks exposure to the supplement, daily 100 mg of isoflavones
Also known as: Mega Soja - Springfield
Gene-expression in PBMCs
after placebo vs after treatment measured by microarrays
Time frame: after 8 weeks exposure to supplement vs after 8 weeks exposure to placebo
Isoflavone levels in plasma
after placebo vs after treatment measured by HPLC
Time frame: before and after 8 weeks exposure to supplement vs before and after 8 weeks exposure to placebo
Gene - expression in adipose tissue
after placebo vs after treatment measured by QPCR
Time frame: after 8 weeks exposure to supplement vs after 8 weeks exposure to placebo
Isoflavone levels in adipose tissue
levels after placebo vs levels after treatment measured by HPLC
Time frame: after 8 weeks exposure to supplement vs after 8 weeks exposure to placebo
This study is completed, as verified in Oct 2012. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Wageningen University