A Phase 1 interventional study of Hand grip maneuver in Orthostatic Hypotension, sponsored by Tel-Aviv Sourasky Medical Center. Status unknown at 1 site in Israel. Open to participants aged 18 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2012-01-30.
Sponsored by Tel-Aviv Sourasky Medical Center · Phase 1, Interventional, and Prevention
The study is aimed to assess the efficacy of hand-grip in preventing orthostatic hypotension in 20 patients diagnosed with autonomic failure. Five healthy subjects will be studied for comparison. The investigators will evaluate the subjects while on tilt table for 10 minutes and than while mounted from lying down to 70 degrees for additional 10 minutes. Blood pressure, heart rate and symptoms will be continuously measured. First study will evaluate the blood pressure changes. Second measure will include hand-grip maneuver 1 minute before the erect positon. Trans cranial Doppler will assess the intracranial blood flow during the position changes.
Study 1:
10 minutes lying on the tilt table. Performing TCD study at 10 minutes. Raising the tilt table to 70 degrees. Performing TCD study 5 minutes after tilting. Measuring blood pressure and symptoms for 10 minutes. Returning the tilt bed to supine position.
Study 2. in continue with study 1:
10 minutes lying on the tilt table. Performing TCD study at 10 minutes. Performing hand-grip at 50-70% grip force for 1 minute Raising the tilt table to 70 degrees. Performing TCD study 5 minutes after tilting. Measuring blood pressure and symptoms for 10 minutes. Returning the tilt bed to supine position.
155 studies on the registry are indexed under Hypotension, Orthostatic; 34 are open to participants now.
This study's planned enrollment of 20 is below the median of 30 across 113 interventional studies indexed under Hypotension, Orthostatic.
Browse Hypotension, Orthostatic studies →Tel-Aviv Sourasky Medical Center is the lead sponsor of 541 studies on the registry; 49 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Patients with autonomic failure.
Other: Hand grip maneuver
Control group
Other: Hand grip maneuver
Hand grip on blood pressue cuff slightly inflated at 50-70% of maximal force for 1 minute
Change in orthostatic blood fall after tilting with and without hand grip.
Patients will be tilted to 70 degrees twice. Hand grip maneuver will be performed 1 minute before the second tilt study and the differences in blood pressure changes \[baseline-end tilt (mmHg)\] will be compared between the two studies and to those obtained from a healthy control group.
Time frame: 10 minutes after tilting the subjects.
Change in the intracranial blood flow after tilting with and without hand grip.
Intracranial blood flow will be evaluated by transcranial doppler at baseline and after tilting. Differences will be compared \[peak systolic flow (PSW) cm/sec\], after tilting with and without prior hand grip and in comparison to tilting a control group.
Time frame: 10 minutes after tilting.
This study is status unknown, as verified in Jan 2012. You cannot join it, but the record below documents what was studied.
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Tel-Aviv Sourasky Medical Center