ClinicalTrials.gg
Enrolling by invitationNCT01517425iPSCUpdated Jan 16, 2025

Evaluating Cardiovascular Phenotypes Using Induced Pluripotent Stem Cells

An observational study in Coronary Artery Disease, sponsored by Scripps Translational Science Institute. Enrolling by invitation at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-01-16.

Sponsored by Scripps Translational Science Institute · Observational

From the registry’s dates

  • Primary completion was expected by Jul 2025, 1 year 4 months ago, but the record still lists the study as enrolling by invitation.
Study type
Observational
Model
Case-control
Time perspective
Retrospective
Enrollment
200
Ages
18 Years and older
Sex
All
01

Study summary

This research is being done to understand how changes in DNA may put people at risk for developing coronary artery disease. Stem cells will be made using cells from blood and/or skin biopsy samples. We are trying to understand which specific changes in DNA negatively impact a person's health.

02

Conditions studied

  • Coronary Artery Disease
03

In context

Coronary Artery Disease

4,857 studies on the registry are indexed under Coronary Artery Disease; 890 are open to participants now.

This study's planned enrollment of 200 is below the median of 320 across 1,687 observational studies indexed under Coronary Artery Disease.

Browse Coronary Artery Disease studies →

Lead sponsor

Scripps Translational Science Institute is the lead sponsor of 53 studies on the registry; 13 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Subjects previously enrolled in the Scripps Genebank or Healthy Elderly Active Longevity (HEAL) Cohort

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Cases:

  1. Previously enrolled in the CAD module of the Genebank at Scripps Clinic Registry
  2. Eligible to have their blood drawn
  3. Be reliable, cooperative and willing to comply with all protocol-specified procedures
  4. Able to understand and grant

Controls:

  1. Previously enrolled in the Healthy Elderly Active Longevity (HEAL) Cohort
  2. Eligible to have their blood drawn
  3. Be reliable, cooperative and willing to comply with all protocol-specified procedures
  4. Able to understand and grant informed consent

Exclusion criteria

Exclusion Criteria:

  1. Unwilling or unable to grant .
  2. Have a significant medical condition that in the Investigator's opinion may interfere with subject's study participation.
Terms in these criteria, in plain language(1)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

Informed consent

Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.

You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.

05

Study design

Observational model
Case-control
Time perspective
Retrospective
Enrollment
200 participants (estimated)

Groups and cohorts

  • Cases

    Subjects previously enrolled in the Scripps Genebank Study

  • Controls

    Subjects previously enrolled in the Scripps Healthy Elderly Active Longevity (HEAL) Cohort

06

What researchers measure

Primary outcomes

  1. iPSC development

    Develop methods of iPSC generation from patients with genomic risk.

    Time frame: five years

07

Study locations

1 site
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 16, 2025, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT01517425
Lead sponsor
Scripps Translational Science Institute
Responsible party
Eric Topol, MD (Director, Scripps Translational Science Institute, Scripps Translational Science Institute) — Principal investigator
First posted
Jan 25, 2012
Start date
Nov 2012
Primary completion
Jul 2025 (estimated)
Completion
Jul 2030 (estimated)
Last update
Jan 16, 2025

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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No contact was published for this record. The registry link below has the sponsor’s details.

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