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CompletedNCT01508351Updated Apr 29, 2015

The Hypotensive Effect of Propofol: an Observational Study

An observational study in Hypotension and Anesthesia, sponsored by Milton S. Hershey Medical Center. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2015-04-29.

Sponsored by Milton S. Hershey Medical Center · Observational

Study type
Observational
Model
Case-only
Time perspective
Prospective
Enrollment
100
Ages
18 Years and older
Sex
All
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Study summary

Hypotension is a recognized frequent complication of induction of anesthesia. The intent of this research is to determine the incidence of hypotension in patients receiving anesthetic induction with propofol. This investigation seeks to examine how normal clinical practice or a "real world" understanding of the usual response to propofol affects hemodynamics without isolating or standardizing other variables. The current research concerns hypotension in normal clinical practice where variability exists. This project aims to gather information and data in an attempt to form a foundation upon which each of the other variables affecting blood pressure may be subsequently assessed.

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Conditions studied

  • Hypotension
  • Anesthesia

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Keywords

  • Propofol
  • Induction
  • Hypotension
  • General population
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In context

Hypotension

1,021 studies on the registry are indexed under Hypotension; 172 are open to participants now.

This study's enrollment of 100 is above the median of 84 across 301 observational studies indexed under Hypotension.

Browse Hypotension studies →

Lead sponsor

Milton S. Hershey Medical Center is the lead sponsor of 491 studies on the registry; 59 are open to participants now.

Of its 58 completed or terminated interventional studies of FDA-regulated products, 44 (76%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Hershey Medical Center patients presenting for surgery.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • All ASA 1-3 patients who are to receive propofol induction for general anesthesia

Exclusion criteria

Exclusion Criteria:

  • Allergy to propofol
  • ASA 4 and above
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Study design

Observational model
Case-only
Time perspective
Prospective
Enrollment
100 participants (actual)

Groups and cohorts

  • Propofol Induction

    All patients receiving propofol induction of anesthesia who are ASA 1-3

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What researchers measure

Primary outcomes

  1. The systolic, diastolic, and mean arterial pressure.

    The systolic, diastolic, and mean arterial pressure will be measured every minute for twenty minutes. Blood pressure readings of Mean Arterial Pressure less than 65mmHg, Systolic Blood Pressure less than 80mmHg, or Diastolic Blood Pressure less than 40mmHg will be considered as hypotension.

    Time frame: Within first 20 minutes after anesthesia induction

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Study locations

1 site
  • Milton S. Hershey Medical Center
    Hershey, Pennsylvania 17033, United States
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 29, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01508351
Responsible party
Thomas Verbeek (Assistant Professor, Anesthesiology, Milton S. Hershey Medical Center) — Principal investigator
First posted
Jan 11, 2012
Start date
May 2012
Primary completion
Mar 2013
Completion
Mar 2013
Last update
Apr 29, 2015

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2015. You cannot join it, but the record below documents what was studied.

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Discussion

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