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CompletedNCT01470391Updated Dec 18, 2012

Adductor-Canal-Blockade Versus the Femoral Nerve Block Effect on Muscle Strength, Pain and Mobilization After Total Knee Replacement

An interventional study of Adductor-Canal-Blockade and Femoral Nerve Block in Total Knee Arthroplasty, sponsored by Rigshospitalet, Denmark. Completed at 1 site in Denmark. Open to participants aged 50 Years to 85 Years. Per ClinicalTrials.gov, last updated 2012-12-18.

Sponsored by Rigshospitalet, Denmark · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
54
Allocation
Randomized
Ages
50 Years to 85 Years
Sex
All
01

Study summary

The aim of this study is to investigate the efficacy of the Adductor-Canal-Blockade versus the Femoral Nerve Block on muscle strength, pain and mobilization after total knee arthroplasty. We hypothesize that the Adductor-Canal-Blockade has the same effect on pain and morphine consumption as the Femoral Nerve Block, but without the same reduction in quadriceps muscle strength.

02

Conditions studied

  • Total Knee Arthroplasty

Keywords

  • Adductor-Canal-Blockade
  • Femoral Nerve Block
  • Postoperative Pain
  • Total Knee Arthroplasty
03

In context

Lead sponsor

Rigshospitalet, Denmark is the lead sponsor of 1,017 studies on the registry; 183 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
50 Years to 85 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • ASA 1-3
  • BMI > 18 og \< 40
  • total knee arthroplasty in spinal anesthesia

Exclusion criteria

Exclusion Criteria:

  • Can not cooperate to the exam
  • Do not speak or understand Danish
  • Drug allergy
  • Alcohol or drug abuse
  • Daily consumption of strong opioids
  • Rheumatoid arthritis
  • Intake of glucocorticoids
  • Effect of spinal anesthesia stopped prior to performing the regional block
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Quadruple (Participant, Care provider, Investigator, Outcomes assessor)
Enrollment
54 participants (actual)

Study arms

  • Experimental
    Adductor-Canal-Blockade

    Procedure: Adductor-Canal-Blockade

  • Active comparator
    Femoral Nerve Block

    Procedure: Femoral Nerve Block

Interventions

  • ProcedureAdductor-Canal-Blockade

    US-guided Adductor-Canal-Blockade with Ropivacaine

  • ProcedureFemoral Nerve Block

    US-guided Femoral Nerve Block with Ropivacaine

06

What researchers measure

Primary outcomes

  1. The difference in quadriceps muscle strength between the Adductor-Canal-Blockade and the femoral nerve block

    Time frame: 24 h postoperatively

Secondary outcomes

  1. The difference in adductor muscle strength between the Adductor-Canal-Blockade and the Femoral Nerve Block

    Time frame: 24 h postoperatively

  2. Pain during flexion of the knee

    0-100 mm at a visual analogue scale (VAS), calculated as the area under the curve for the interval 2-24 hours postoperatively.

    Time frame: 2-24 hours

  3. Pain at rest

    0-100 mm at a visual analogue scale (VAS), calculated as the area under the curve for the interval 2-24 hours postoperatively.

    Time frame: 2-24 hours

  4. Total morphine consumption

    Time frame: 0-24 hours

  5. Postoperative nausea

    Time frame: 2-24 hours

  6. Postoperative vomiting

    Time frame: 0-24 hours

  7. Sedation

    Time frame: 2-24 hours

  8. Zofran consumption

    Number of patients recieveing zofran postoperatively

    Time frame: 0-24 hours

  9. The difference in mobilization between the groups

    Time frame: 24 hours

07

Study locations

1 site
  • Department of Anaesthesia, Copenhagen University Hospital, Frederiksberg
    Frederiksberg, 2000, Denmark
08

References and documents

Publications

  • Jaeger P, Zaric D, Fomsgaard JS, Hilsted KL, Bjerregaard J, Gyrn J, Mathiesen O, Larsen TK, Dahl JB. Adductor canal block versus femoral nerve block for analgesia after total knee arthroplasty: a randomized, double-blind study. Reg Anesth Pain Med. 2013 Nov-Dec;38(6):526-32. doi: 10.1097/AAP.0000000000000015. PubMed 24121608 ↗
09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Dec 18, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT01470391
Lead sponsor
Rigshospitalet, Denmark
Responsible party
Pia Jaeger (MD, Rigshospitalet, Denmark) — Principal investigator
First posted
Nov 11, 2011
Start date
Nov 2011
Primary completion
Nov 2012
Completion
Nov 2012
Last update
Dec 18, 2012

Study contacts

Pia Jæger, MD
principal investigator · Rigshospitalet, Denmark

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

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