An observational study in Hyponatremia and Hypernatremia, sponsored by University Hospital, Basel, Switzerland. Completed at 2 sites in Switzerland. Open to participants aged 18 Years to 110 Years. Per ClinicalTrials.gov, last updated 2015-12-02.
Sponsored by University Hospital, Basel, Switzerland · Observational
Background: Hypo- and hypernatremia are common in hospitalized patients. The differential diagnosis of dysnatremia is challenging.
Osmotically inadequate secretion of antidiuretic hormone (ADH) is the predominant mechanism in most dysnatremic disorders. ADH measurement is cumbersome. It is derived from a larger precursor peptide along with copeptin, which is a more stable peptide directly mirroring the production of ADH.
Objective: To evaluate the additional value of copeptin to improve a currently used algorithm in the differential diagnosis of (A) severe hypoosmolar hypo- and (B) severe hypernatremia.
Design: Prospective observational study.
156 studies on the registry are indexed under Hyponatremia; 17 are open to participants now.
This study's enrollment of 300 is above the median of 190 across 58 observational studies indexed under Hyponatremia.
Browse Hyponatremia studies →University Hospital, Basel, Switzerland is the lead sponsor of 989 studies on the registry; 191 are open to participants now.
Counted across the registry records on this site, refreshed daily.
hospitalized patients with severe hypo or hypernatremia
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
hospitalized patients with hyponatremia
diagnostic accuracy of copeptin within hospital stay
diagnostic accuracy will be determined by receiver operated curve (ROC) analysis. The study is powered to detect a difference of copeptin levels between patients with partial central diabetes insipidus (DI) and patients with primary polydipsia.
Time frame: participants will be followed for up to 1 year
This study is completed, as verified in Nov 2015. You cannot join it, but the record below documents what was studied.
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University Hospital, Basel, Switzerland →